上海药物所构建三元协同纳米粒攻破三阴性乳腺癌的免疫抑制网络

Shanghai Institute of Materia Medica constructed ternary synergistic nanoparticles to break through the immunosuppressive network of triple negative breast cancer

近日,中国科学院上海药物研究所李亚平课题组在ACS Nano发表了题为“Breaking tumor immunosuppressive network by regulating multiple nodes with triadic drug delivery nanoparticle”的研究论文。该研究构建了具有级联酸敏感的三元协同纳米粒,其可同时重编程TAM、抑制MDSC和阻断PD-1/PD-L1通路.