左乙拉西坦联合丙戊酸钠在颅脑外伤术后并发癫痫患者中的应用

Application of levetiracetam combined with sodium valproate in patients with epilepsy after craniocerebral trauma surgery

目的此研究旨在探讨左乙拉西坦联合丙戊酸钠在颅脑外伤术后并发癫痫患者中的应用效果。方法选取云浮市人民医院2021年1月-2022年12月收治的颅脑外伤术后并发癫痫的患者103例为研究对象,根据患者意向分为观察组与对照组。对照组采用丙戊酸钠单药治疗,观察组采用左乙拉西坦联合丙戊酸钠治疗,比较两组治疗前后癫痫发作的次数和持续时间,以及治疗前后认知功能、生活质量评分和不良反应发生率。结果治疗后,观察组治疗总有效率(90.00%)明显高于对照组(77.36%),差异有统计学意义(P<0.05);治疗前,两组患者癫痫发作情况对比,差异无统计学意义(P>0.05);治疗后两组患者癫痫发作的次数和持续时间均降低,且观察组要低于对照组,差异有统计学意义(P<0.05);治疗前,两组患者认知功能与生活质量评分对比,差异无统计学意义(P>0.05);治疗后观察组认知功能、心理健康、身体功能、社会功能评分均优于对照组,且差异有统计学意义(P<0.05);两组不良反应发生率比较,观察组(11.32%)显著低于对照组的(30.19%),差异有统计学意义(P<0.05)。结论左乙拉西坦联合丙戊酸钠治疗颅脑外伤术后并发癫痫是一种有效的治疗方法,值得临床应用和推广。

Objective The purpose of this study was to explore the effect of levetiracetam combined with sodium valproate in patients with epilepsy after craniocerebral trauma surgery.Method 103 patients with postoperative epilepsy risk after craniocerebral injury admitted to our hospital from January 2021 to December 2022 were selected as the research subjects,and were divided into an observation group and a control group based on patient intentions.The control group was treated with sodium valproate alone,and the observation group was treated with levetiracetam combined with sodium valproate.The frequency,time and duration of seizure before and after treatment,as well as cognitive function,quality of life scores and incidence of adverse reactions were compared between the two groups.Result After treatment,the total effective rate of the observation group(90.00%)was significantly higher than that of the control group(77.36%),with a statistically significant difference(P<0.05);before treatment,there was no significant difference between the two groups in seizure(P>0.05);after treatment,the frequency and duration of seizures in both groups of patients decreased,and the difference between the control group and the observation group was statistically significant(P<0.05);before treatment,there was no statistically significant difference in cognitive function and quality of life scores between the two groups of patients(P>0.05);after treatment,the cognitive function,mental health,physical function,and social function scores of the observation group were better than those of the control group,and the difference was statistically significant(P<0.05);the incidence of adverse reactions between the two groups was significantly lower in the observation group(11.32%)than in the control group(30.19%),with a statistically significant difference(P<0.05).Conclusion Levetiracetam combined with sodium valproate is an effective treatment for epilepsy after craniocerebral trauma surgery,which is worthy of clinical application and promotion.