摘要
含有3-酰基特特拉姆酸结构单元的天然产物数量巨大,结构复杂多样,表现出了抗菌、抗病毒、抗肿瘤等多种生物活性,尤以抗菌活性最为突出,被看作是新型抗生素的潜在储库。本文按照化合物的结构特征分类,综述了各类含有3-酰基特特拉姆酸结构单元的天然产物的抗菌活性,以及含有3-酰基特特拉姆酸结构单元的天然产物的研究新热点、新方向。
The natural products containing 3-acyl tetramic acid units have a large number of complex and diverse structures,showing a variety of biological activities such as antibacterial,antiviral,anti-tumor and so on,especially antibacterial activity which are regarded as a potential reservoir of new antibiotics.In this paper,the antibacterial activities of various natural products containing 3-acyl tetramic acids and the new research hotspots and directions are reviewed.
作者
马彩云
刘站柱
潘璇
MA Cai-yun;LIU Zhan-zhu;PAN Xuan(State Key Laboratory of Bioactive Substance and Function of Nature Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)
出处
《药学学报》
CAS
CSCD
北大核心
2023年第12期3572-3582,共11页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81903522)
中国医学科学院医学与健康科技创新工程(2022-I2M-JB-011)。
关键词
耐药菌
3-酰基特特拉姆酸
天然产物
抗菌活性
金属螯合
drug-resistant bacteria
3-acyl-tetramic acid
natural product
antibacterial activity
metal-chelating
