摘要
通过大孔吸附树脂、MCI树脂、HW-40C凝胶树脂和Sephadex LH-20凝胶柱色谱,以及制备薄层、反相HPLC和Flash等色谱分离技术相结合,从玄参科鹿茸草水煎煮提取物中分离得到12个化合物,包括5个新单萜和7个已知化合物。借助波谱数据解析、酶水解以及电子圆二色谱(ECD)和NMR计算,综合分析鉴定了它们的结构;其中新化合物分别命名为鹿茸草苷I (1)和鹿茸草醇A~D (2~5)。已知化合物6~12均为首次从鹿茸草属植物中分离得到。
Twelve compounds,including 5 new monoterpenes and 7 known derivatives,were isolated from a water decoction of Monochasma savatieri by column chromatography over macroporous adsorbent resin,MCI resin,Sephadex LH-20,and HW-40C,combined with preparative TLC,reversed phase HPLC,and flash column chromatographic techniques.Their structures were elucidated by comprehensive analysis of spectroscopic data,along with enzymatic hydrolysis as well as electronic circular dichroism(ECD)and NMR calculations,the new structures named monochaside I(1)and monochairidols A-D(2-5),respectively.The known compounds 6-12 were obtained from the Monochasma plants for the first time.
作者
刘琛
徐成博
朱承根
雷小强
穆滨
石建功
郭庆兰
LIU Chen;XU Cheng-bo;ZHU Cheng-gen;LEI Xiao-qiang;MU Bin;SHI Jian-gong;GUO Qing-lan(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;Harbin Kanglong Pharmaceutical Co.,Ltd.,Harbin 150025,China)
出处
《药学学报》
CAS
CSCD
北大核心
2023年第12期3701-3709,共9页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目[82293681,82293685(82293680)]
中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-028).
关键词
玄参科
鹿茸草
水提取物
鹿茸草苷
鹿茸草醇
Scrophulariaceae
Monochasma savatieri
aqueous extract
monochaside I
monochairidol