阻塞性睡眠呼吸暂停与血管性认知损害:血脑屏障受损的作用

Obstructive sleep apnea and vascular cognitive impairment: role of blood-brain barrier impairment

阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)是一种睡眠障碍,其主要特征是睡眠期间反复发作的上呼吸道阻塞、睡眠片段化和缺氧等。该病常会导致患者出现认知、情感、记忆等相关神经方面的损伤,其机制与血脑屏障(blood-brain barrier,BBB)破坏密切相关。文章主要探讨了OSAS引起的BBB受损与血管性认知损害(vascular cognitive impairment,VCI)之间的关系,以及早期预防、干预和修复BBB对减轻VCI的作用。

Obstructive sleep apnea(OSA)is a sleep disorder characterized by recurrent upper respiratory tract obstruction,sleep fragmentation,and hypoxia during sleep.This disease often leads to cognitive,emotional,and memory related neurological damage,and its mechanism is closely associated with the disruption of the blood-brain barrier(BBB).This article mainly discusses the relationship between BBB damage caused by OSA and vascular cognitive impairment(VCI),as well as the role of early prevention,intervention,and repairing BBB on reducing VCI.