SIRT1/FoxO1通路在脑缺血再灌注损伤中的研究进展

Advances in SIRT1/FoxO1 Pathway in Cerebral Ischemia-Reperfusion Injury

缺血性脑卒中已经成为危害我国居民生命健康的首要疾病,主要治疗方式是通过溶栓或机械取栓重建缺血区血流,但血流复灌后可能会引发脑缺血再灌注损伤(CIRI),严重影响缺血性脑卒中患者的康复,故如何减轻CIRI是改善缺血性脑卒中预后的关键问题。沉默信息调节因子1(SIRT1)是一种组蛋白去乙酰化酶,可通过去乙酰化作用调节其下游分子叉头框蛋白O1(FoxO1)的活性。SIRT1/FoxO1通路与CIRI的神经保护作用密切相关,其机制可能涉及减轻炎症反应、抗氧化应激、抑制细胞凋亡、调节自噬等方面,可作为治疗缺血性脑卒中的新靶点。

Ischemic stroke has become the primary disease that threatens the life and health of Chinese residents.The main treatment is to rebuild the blood flow in the ischemic area through thrombolysis or mechanical thrombolysis.However,after reperfusion of blood flow,cerebral ischemia-reperfusion injury(CIRI)may be caused,which seriously affects the rehabilitation of the patients.Therefore,how to reduce CIRI is the key to improve the prognosis of ischemic stroke.Silent information regulator 1(SIRT1)is a histone deacetylase that regulates the activity of its downstream molecule forkhead box protein O1(FoxO1)through deacetylation.SIRT1/FoxO1 pathway is closely related to the neuroprotective effect of CIRI,and its mechanism may involve reducing inflammatory response,anti-oxidative stress,inhibiting apoptosis,and regulating autophagy,which can be used as a new target for the treatment of ischemic stroke.