内膜厚度与体外受精-胚胎移植妊娠结局的研究进展

Effect of endometrial thickness on in vitro fertilization-embryo transfer pregnancy outcome:a review of research progress

子宫内膜容受性是体外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)技术实现临床妊娠的关键,子宫内膜厚度(endometrial thickness,EMT)是其代表性的监测指标,但代表子宫内膜容受性的最佳内膜时机是存在争议的。许多研究证明了EMT与IVF妊娠结局的相关性,适度的EMT范围是良好妊娠结局所不可或缺的,而薄型子宫内膜对妊娠结局存在不良影响。本文结合最新研究进展,主要从EMT测量时机、临床妊娠率、活产率、异位妊娠率、前置胎盘及低出生体重等方面阐述EMT对IVF-ET妊娠结局的影响,以及阐述薄型子宫内膜的发生机制和治疗,供临床工作参考以改善IVF妊娠结局。

Endometrial receptivity is key to clinical pregnancy by in vitro fertilization-embryo transfer(IVF-ET)technique.Endometrial thickness(EMT)is a major index for pregnancy monitoring,but the optimal time indicating endometrial receptivity is controversially uncertain.Multiple studies have demonstrated the correlation between EMT and IVF pregnancy outcomes and EMT of a moderate range is essential for good pregnancy outcomes and a thin endometrium produces negative pregnancy outcomes.In this paper,we reviewed the research on the im⁃pact of EMT on IVF-ET pregnancy outcomes in terms of timing of EMT measurement,clinical pregnancy rate,live birth rate,ectopic pregnancy rate,placenta praevia,and low birth weight,investigating the mechanism of occur⁃rence and treatment of thin endometrium so as to provide clinical references for improving IVF pregnancy outcomes.