内镜下黏膜切除术治疗结肠息肉的效果及对血清炎症因子水平的影响探讨

The effect of endoscopic mucosal resection in the treatment of colonic polyps and its influence on serum level of inflammatory factors

目的探讨内镜下黏膜切除术治疗结肠息肉的效果及对患者血清炎症因子水平的影响。方法110例结肠息肉患者,按照手术方式不同分为参照组和实验组,每组55例。参照组接受内镜下高频电凝电切术治疗,实验组接受内镜下黏膜切除术治疗。比较两组的临床疗效、手术相关指标、血清炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)、白细胞介素-1(IL-1)]。结果实验组总有效率94.55%高于参照组的80.00%,差异具有统计学意义(P<0.05)。实验组手术时间(48.54±3.61)min、首次排气时间(26.45±5.86)h、首次排便时间(36.92±6.14)h、创面愈合时间(27.46±4.62)d、住院时间(5.28±1.45)d均短于参照组的(60.08±4.53)min、(30.27±6.49)h、(41.29±7.83)h、(30.85±5.80)d、(8.53±1.69)d,差异具有统计学意义(P<0.05)。治疗后,两组IL-1、IL-6、CRP、TNF-α水平均低于治疗前,且实验组IL-1(19.36±1.10)ng/L、IL-6(98.87±3.38)ng/L、CRP(2.86±0.57)mg/L、TNF-α(39.78±2.21)ng/L均低于参照组的(20.06±1.28)ng/L、(101.13±3.46)ng/L、(5.75±0.68)mg/L、(41.35±2.46)ng/L,差异具有统计学意义(P<0.05)。结论结肠息肉患者应用内镜下黏膜切除术治疗具有显著效果,可缩短手术时间、首次排气时间、首次排便时间、创面愈合时间、住院时间,降低患者的炎性因子水平。

Objective To discuss the effect of endoscopic mucosal resection in the treatment of colonic polyps and its influence on serum level of inflammatory factors.Methods A total of 110 patients with colonic polyps were divided into the reference group and the experimental group according to different surgical methods,with 55 cases in each group.The reference group was treated with endoscopic high-frequency electrocoagulation electrotomy,and the experimental group was treated with endoscopic mucosal resection.The clinical efficacy,surgery-related indexes and serum inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP),interleukin-1(IL-1)]of the two groups were compared.Results The total effective rate of the experimental group was 94.55%,which was higher than that of 80.00%of the reference group,and the difference was statistically significant(P<0.05).The experimental group had operative time of(48.54±3.61)min,first exhaust time of(26.45±5.86)h,first defecation time of(36.92±6.14)h,wound healing time of(27.46±4.62)d and hospital stay of(5.28±1.45)d,which were all shorter than those of(60.08±4.53)min,(30.27±6.49)h,(41.29±7.83)h,(30.85±5.80)d and(8.53±1.69)d in the reference group,and the differences were statistically significant(P<0.05).After treatment,the levels of IL-1,IL-6,CRP and TNF-αin both groups were lower than those before treatment in this group;the experimental group had IL-1 of(19.36±1.10)ng/L,IL-6 of(98.87±3.38)ng/L,CRP of(2.86±0.57)mg/L and TNF-αof(39.78±2.21)ng/L,which were all lower than those of(20.06±1.28)ng/L,(101.13±3.46)ng/L,(5.75±0.68)mg/L and(41.35±2.46)ng/L in the reference group;the difference were statistically significant(P<0.05).Conclusion For patients with colonic polyps,endoscopic mucosal resection has significant clinical effects,which can shorten the operative time,first exhaust time,first defecation time,wound healing time,hospital stay,and reduce the level of inflammatory factors in patients.