丁苯酞氯化钠注射液治疗急性脑梗死后失语患者的临床疗效

Clinical efficacy of butylphthalide and sodium chloride injection on aphasia after acute cerebral infarction

目的研究丁苯酞氯化钠注射液治疗急性脑梗死后失语患者的效果。方法84例急性脑梗死后失语患者,随机分为观察组(43例)和对照组(41例)。对照组患者采用常规治疗,观察组在对照组基础上应用丁苯酞氯化钠注射液治疗。比较两组患者治疗前后的语言功能、神经功能以及用药不良反应发生情况。结果治疗后,两组患者美国国立卫生研究院卒中量表(NIHSS)评分低于治疗前,西部失语症检查量表(WAB)评分高于治疗前;观察组患者NIHSS评分(12.49±2.44)分低于对照组的(18.65±3.55)分,WAB评分(86.70±16.94)分高于对照组的(77.85±14.83)分,差异均具有统计学意义(P<0.05)。观察组用药不良反应发生率11.63%与对照组的9.76%比较,差异无统计学意义(P>0.05)。结论急性脑梗死后失语患者在常规基础上用丁苯酞氯化钠注射液能改善患者神经功能和语言功能,且不会产生严重的不良反应,值得推荐。

Objective To study the effect of butylphthalide and sodium chloride injection on aphasia after acute cerebral infarction.Methods A total of 84 patients with aphasia after acute cerebral infarction were randomly divided into an observation group(43 cases)and a control group(41 cases).Patients in the control group were treated with conventional treatment,and patients in the observation group were treated with butylphthalide and sodium chloride injection on the basis of the control group.The language function and neurological function before and after treatment,and the occurrence of adverse drug reactions were compared between the two groups.Results After treatment,the National Institutes of Health Stroke Scale(NIHSS)score in both groups was lower than that before treatment in this group,and the Western Aphasia Battery(WAB)score was higher than before treatment;NIHSS score of(12.49±2.44)points in the observation group was lower than that of(18.65±3.55)points in the control group;WAB score of(86.70±16.94)points in the observation group was higher than that of(77.85±14.83)points in the control group;the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse drug reactions between the observation group(11.63%)and the control group(9.76%)(P>0.05).Conclusion For patients with aphasia after acute cerebral infarction,the use of butylphthalide and sodium chloride injection on the basis of conventional treatment can improve the neurological function and language function of patients,without causing serious adverse reactions,and is worthy of recommendation.