左乙拉西坦联合奥卡西平治疗小儿癫痫的临床效果分析

Clinical Effect Analysis of Levetiracetam Combined with Oxcarbazepine in Treatment of Epilepsy in Children

目的:分析左乙拉西坦联合奥卡西平治疗小儿癫痫的临床效果。方法:选取2021年6月—2022年7月菏泽市成武县人民医院收治的癫痫患儿76例作为研究对象,随机分为常规组与研究组,各38例。常规组采用奥卡西平治疗,研究组在对照组基础上采用左乙拉西坦治疗。比较两组临床疗效、不良反应发生情况、认知功能、脑电图指数。结果:研究组治疗有效率高于常规组,差异有统计学意义(P=0.024 9)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗前,两组操作智商(PIQ)、语言智商(VIQ)、总智商(FIQ)评分比较,差异无统计学意义(P>0.05);治疗后,两组PIQ、VIQ、FIQ评分高于治疗前,且研究组高于常规组,差异有统计学意义(P<0.05)。治疗前,两组α波、β波、δ波、θ波指数比较,差异无统计学意义(P>0.05);治疗后,两组α、β波高于治疗前,且研究组高于常规组,两组δ、θ波低于治疗前,且研究组低于常规组,差异有统计学意义(P<0.05)。结论:左乙拉西坦联合奥卡西平治疗小儿癫痫的临床效果显著,可改善患儿认知与神经功能,且不会增加不良反应。

Objective:To analyze the clinical effect of levetiracetam combined with oxcarbazepine in the treatment of epilepsy in children.Methods:A total of 76 children with epilepsy who were treated in Heze City Chengwu County People′s Hospital from June 2021 to July 2022 were selected as the study subjects.They were randomly divided into conventional group and study group,with 38 cases in each group.The conventional group was treated with oxcarbazepine and the study group was treated with levetiracetam on the basis of control group.Clinical efficacy,incidence of adverse reactions,cognitive function,and EEG index were compared between two groups.Results:The effective rate of treatment in the study group was higher than that in the conventional group,and the difference was statistically significant(P=0.0249).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Before treatment,there was no significant difference in the scores of performance intelligence quotient(PIQ),verbal intelligence quotient(VIQ)and full-scale intelligence quotient(FIQ)between the two groups(P>0.05);after treatment,the scores of PIQ,VIQ and FIQ in the two groups were higher than those before treatment,and the scores in the study group were higher than those in the conventional group,with statistically significant difference(P<0.05).Before treatment,there was no significant difference in theαwave index,βwave index,δwave index andθwave index between the two groups(P>0.05);after treatment,theαandβwaves in the two groups were higher than those before treatment,and the study group was higher than the conventional group,while theδandθwaves in the two groups were lower than those before treatment,and the study group was lower than the conventional group,and the difference was statistically significant(P<0.05).Conclusion:The clinical effect of levetiracetam combined with oxcarbazepine in the treatment of epilepsy in children is remarkable,which can improve cognitive and neurological function in children,and will not increase adverse reactions.