低分子肝素联合间苯三酚治疗妊娠晚期羊水过少的临床效果

Clinical Effect of Low-Molecular-Weight Heparin Combined with Phloroglucinol in Treatment of Oligohydramnios inLate Trimester of Pregnancy

目的:探讨低分子肝素联合间苯三酚治疗妊娠晚期羊水过少的临床效果。方法:选取2020年1月—2021年1月长沙市妇幼保健院收治的100例妊娠晚期羊水过少患者作为研究对象,根据随机数字表法分为观察组和对照组,各50例。对照组采取常规治疗,观察组在对照组基础上应用低分子肝素以及间苯三酚治疗。比较两组治疗效果。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.027)。治疗前,两组羊水指数(AFI)、最大羊水池深度(AFD)、脐动脉收缩期最大血流速度和舒张期末血流速度比值(S/D)比较,差异无统计学意义(P>0.05);治疗后,两组AFI、AFD高于治疗前,且观察组高于对照组,两组S/D低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)比较,差异无统计学意义(P>0.05);治疗后,两组PT、APTT和TT均长于治疗前,且观察组长于对照组,差异有统计学意义(P<0.05)。结论:低分子肝素联合间苯三酚治疗妊娠晚期羊水过少的临床效果显著,可增加患者羊水量,改善患者血流指标与凝血功能。

Objective:To explore the clinical effect of low-molecular-weight heparin combined with phloroglucinol in treatment of oligohydramnios in the late trimester of pregnancy.Methods:From January 2020 to January 2021,100 patients with oligohy⁃dramnios in the late trimester of pregnancy who were admitted to Changsha Hospital for Maternal&Child Health Care were se⁃lected as the study subjects.They were divided into control group and observation group according to random number table method,with 50 cases in each group.The control group received conventional treatment,and the observation group received lowmolecular-weight heparin combined with phloroglucinol treatment.The treatment effects were compared between the two groups.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.027).Before treatment,there was no significant difference in amniotic fluid index(AFI),maxi⁃mum amniotic fluid depth(AFD),umbilical artery systolic peak velocity and diastolic peak velocity ratio(S/D)between the two groups(P>0.05).After treatment,the AFI and AFD in the two groups were higher than those before treatment,and the observation group was higher than the control group,while the S/D in the two groups was lower than that before treatment,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no sig⁃nificant difference in prothrombin time(PT),activated partial thromboplastin time(APTT)and thrombin time(TT)between the two groups(P>0.05).After treatment,PT,APTT and TT in the two groups were longer than those before treatment,and the observation group was longer than the control group,and the difference was statistically significant(P<0.05).Conclusion:The clinical effect of low-molecular-weight heparin combined with phloroglucinol in treatment of oligohydramnios in the late trimester of pregnancy is significant,which can increase the amount of amniotic fluid and improve the blood flow index and coagulation function of patients.