新生儿高胆红素血症与产妇孕晚期维生素D 水平的相关性分析

Correlation Analysis Between Neonatal Hyperbilirubinemia and Maternal Vitamin D Levels in Late Pregnancy

目的:分析新生儿高胆红素血症与产妇孕晚期维生素D水平的相关性。方法:回顾性分析2021年1月—2022年12月在银川市第一人民医院妇保科出生的300对母婴的临床资料,根据新生儿出生后高胆红素血症发生情况分为高胆红素血症组(n=57)与无高胆红素血症组(n=243),比较两组产妇孕晚期血清25-羟维生素D水平及维生素D补充情况;根据孕妇孕晚期是否补充维生素D将其分为补充组(n=246)与未补充组(n=54),采用Spearman相关系数分析新生儿胆红素水平与产妇孕晚期血清25-羟维生素D水平和维生素D补充情况的相关性。结果:高胆红素血症组25-羟维生素D水平低于无高胆红素血症组,维生素D补充率低于无高胆红素血症组,差异有统计学意义(P<0.001)。未补充组新生儿血清总胆红素、直接胆红素、间接胆红素水平均高于补充组,差异有统计学意义(P<0.001)。新生儿血清总胆红素、直接胆红素、间接胆红素水平与孕妇孕晚期血清25-羟维生素D水平、维生素D补充均呈负相关,差异有统计学意义(P<0.05)。结论:新生儿高胆红素血症与孕妇孕晚期维生素水平及维生素D补充情况相关,在孕晚期需加强对于孕妇维生素D水平的监测,并积极补充维生素D。

Objective:To analyze the correlation between neonatal hyperbilirubinemia and maternal vitamin D levels in late pregnancy.Methods:Clinical data of 300 pairs of mothers and neonates in the Department of Women's Health at the First People's Hospital of Yinchuan from January 2021 to December 2022 were retrospectively analyzed.The subjects were divided into hyperbilirubinemia group(n=57)and non-hyperbilirubinemia group(n=243)according to the occurrence of neonatal hyperbilirubinemia after birth.The maternal serum 25-hydroxyvitamin D level and vitamin D supplementation in late pregnancy were compared between the two groups.The subjects were divided into supplementation group(n=246)and non-supplementation group(n=54)according to whether they were supplemented with vitamin D in late pregnancy.Spearman correlation coefficient was used to analyze the correlation between neonatal bilirubin level and maternal serum 25-hydroxyvitamin D level and vitamin D supplementation in late pregnancy.Results:The level of 25-hydroxyvitamin D in the hyperbilirubinemia group was lower than that in the nonhyperbilirubinemia group,and the vitamin D supplementation rate in the hyperbilirubinemia group was lower than that in the nonhyperbilirubinemia group,and the difference was statistically significant(P<0.001).The levels of serum total bilirubin,direct bilirubin and indirect bilirubin in the non-supplementation group were higher than those in the supplementation group,and the difference was statistically significant(P<0.001).The levels of serum total bilirubin,direct bilirubin and indirect bilirubin in neonates were negatively correlated with maternal serum 25-hydroxyvitamin D levels and vitamin D supplementation in late pregnancy,and the differences were statistically significant(P<0.05).Conclusions:Neonatal hyperbilirubinemia is associated with maternal vitamin levels and vitamin D supplementation in late pregnancy.Vitamin D levels should be monitored during late pregnancy and vitamin D supplementation should be actively practiced.