艾司氯胺酮对不孕症患者腹腔镜手术后疼痛程度、焦虑及抑郁情绪的影响

Effect of esketamine on pain degree and anxiety and depression in infertile patients after laparoscopic surgery

目的探讨艾司氯胺酮对不孕症患者腹腔镜手术后疼痛程度、焦虑及抑郁情绪的影响。方法选取100例不孕症行腹腔镜手术患者,根据随机数字表法分为对照组与研究组,每组50例。研究组在全身麻醉诱导后静脉缓慢注射盐酸艾司氯胺酮注射液,对照组给予等量0.9%氯化钠注射液。比较两组患者术后恢复效果。结果术后48h研究组前列腺素E_(2)(PGE_(2))水平(123.14±16.43)ng/L及视觉模拟评分法(VAS)评分(3.52±1.32)分均分别低于对照组的(143.14±20.34)ng/L、(6.05±1.59)分(P<0.05)。术后48h研究组焦虑自评量表(SAS)、抑郁自评量表(SDS)评分均明显低于对照组(P<0.05)。术后48h研究组去甲肾上腺素(NE)、肾上腺素(E)指标均较对照组低(P<0.05)。结论艾司氯胺酮可够减轻不孕症患者腹腔镜手术后疼痛程度,改善焦虑、抑郁情绪,还能减轻术后应激反应程度,值得临床推广。

Objective To investigate the effects of esketamine on pain and anxiety and depression in infertile patients after laparoscopic surgery.Methods 10o infertile patients undergoing laparoscopic surgery were selected and divided into control group and study group according to random number table method,with 50 cases in each group.After induction of general anesthesia,the study group was slowly injected with Esketamine hydrochloride injection,while the control group was given 0.9%sodium chloride injection.The postoperative recovery effect was compared between the two groups.Results 48 h after operation,the level of prostaglandin E_(2)(PGE_(2))in the study group(123.14±16.43)ng/L and visual analogue scale(VAS)score(3.52±1.32)points were lower than those in the control group(143.14±20.34)ng/L and(6.05±1.59)points,respectively(P<0.05).The scores of self-rating anxiety scale(SAS)and self-rating depression scale(SDS)in the study group were significantly lower than those in the control group 48 h after surgery(P<0.05).The indexes of norepinephrine(NE)and epinephrine(E)in the study group were lower than those in the control group 48 h after operation(P<0.05).Conclusion Esketamine can alleviate the pain of infertility patients after laparoscopic surgery,improve anxiety and depression,and also reduce the degree of post-operative stress reaction,which is worthy of clinical promotion.