丙硫氧嘧啶治疗妊娠期并甲亢对孕妇甲状腺功能、妊娠结局的影响观察

Effect of propylthiouracil on thyroid function and pregnancy outcome in pregnant women with hyperthyroidism

目的研究妊娠期并甲状腺功能亢进症(甲亢)采用丙硫氧嘧啶治疗对孕妇甲状腺功能、妊娠结局的影响。方法选取106例妊娠期并甲亢孕妇,采用随机数字表法分组,每组53例。对照组采用甲巯咪唑治疗,研究组采用丙硫氧嘧啶治疗。比较两组甲状腺功能变化情况及妊娠结局。结果研究组血清游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))水平明显低于对照组,而促甲状腺素(TSH)水平高于对照组,差异有统计学意义(P<0.05);研究组不良妊娠结局发生率(5.66%)较对照组(24.53%)低,差异有统计学意义(P<0.05)。结论丙硫氧嘧啶治疗妊娠期并甲亢孕妇,可有效改善甲状腺功能,缓解其甲亢症状,从而降低不良妊娠结局的发生风险,具有临床推广与应用价值。

Objective To study the effect of propyrithiouracil on thyroid function and pregnancy outcome in pregnant women with hyperthyroidism.Methods 106 pregnant women with hyperthyroidism were selected and divided by random number table method,with 53 cases in each group.The control group was treated with methimazole and the study group was treated with propylthiouracil.The changes of thyroid function and pregnancy outcome were compared between the two groups.Results Serum levels of free triodothyronine(FT_(3))and free thyroxine(FT_(4))in the study group were significantly lower than those in the control group,while the levels of thyrotropin(TSH)were higher than those in the control group,the difference was statistically significant(P<0.05).The incidence of adverse pregnancy outcome in the study group(5.66%)was lower than that in the control group(24.53%),and the difference was statistically significant(P<0.05).Conclusion Propyrithiouracil in the treatment of pregnant women with hyperthyroidism can effectively improve thyroid function,relieve the symptoms of hyperthyroidism,and reduce the risk of adverse pregnancy outcomes,which has clinical promotion and application value.