国产与进口甘精胰岛素制剂治疗糖尿病的临床效果及安全性比较

Comparison of Clinical Efficacy and Safety of Domestic and Imported Insulin Glargine in the Treatment of Diabetes Mellitus

目的研究国产与进口甘精胰岛素制剂治疗糖尿病的临床效果及安全性。方法选取2020年1月-2022年8月我院诊治的62例糖尿病患者为研究对象,采用随机数字表法分为对照组和观察组,各31例。对照组采用进口甘精胰岛素制剂治疗,观察组采用国产甘精胰岛素制剂治疗,比较两组临床效果、血糖指标[空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)]、血糖达标时间、胰岛素剂量、低血糖发生率、不良反应发生率以及经济成本。结果观察组治疗总有效率为93.55%,低于对照组的96.77%,但差异无统计学意义(P>0.05);两组治疗后FPG、2 hPG、HbA1c水平均低于治疗前(P<0.05),但组间比较,差异无统计学意义(P>0.05);观察组血糖达标时间与对照组比较,差异无统计学意义(P>0.05),但观察组胰岛素剂量小于对照组(P<0.05);观察组低血糖发生率低于对照组,但差异无统计学意义(P>0.05);观察组不良反应发生率低于对照组(P<0.05);观察组用药物费用、治疗总费用均低于对照组(P<0.05)。结论国产甘精胰岛素制剂治疗糖尿病可实现与进口甘精胰岛素制剂相似的治疗效果,且国产甘精胰岛素制剂可改善血糖指标,减小胰岛素剂量,降低不良反应发生率,减少用药物费用和总治疗费用。

Objective To study the clinical effect and safety of domestic and imported insulin glargine in the treatment of diabetes mellitus.Methods A total of 62 diabetic mellitus patients diagnosed and treated in our hospital from January 2020 to August 2022 were selected as the research objects.They were divided into control group and observation group by random number table method,with 31 patients in each group.The control group was treated with imported insulin glargine,and the observation group was treated with domestic insulin glargine.The clinical effects,blood glucose indexes[fasting blood glucose(FPG),2 h postprandial blood glucose(2 hPG),glycosylated hemoglobin(HbA1c)],blood glucose compliance time,insulin dose,incidence of hypoglycemia,incidence of adverse reactions and economic costs were compared between the two groups.Results The total effective rate of the observation group was 93.55%,which was lower than 96.77%of the control group,but the difference was not statistically significant(P>0.05).After treatment,the levels of FPG,2 hPG and HbA1 c in the two groups were lower than those before treatment(P<0.05),but there was no significant difference in blood glucose index between the observation group and the control group(P>0.05).There was no significant difference in the time of blood glucose reaching the standard between the observation group and the control group(P>0.05),but the insulin dose in the observation group was lower than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).The drug cost and total cost of treatment in the observation group were lower than those in the control group(P<0.05).Conclusion Domestic insulin glargine can achieve similar therapeutic effect with imported insulin glargine in the treatment of diabetes mellitus,and domestic insulin glargine can improve blood glucose index,reduce insulin dose,reduce the incidence of adverse reactions,reduce drug costs and total treatment costs.