摘要
目的:探讨异位妊娠(EP)予以甲氨蝶呤与米非司酮联合方案对其血清β-HCG及并发症的影响效果。方法:选择符合保守治疗条件的EP患者78例进行研究,双色球法分为2组,包括对照组(甲氨蝶呤治疗,n=39)与观察组(甲氨蝶呤+米非司酮治疗,n=39),于2017年6月—2021年6月收治。对比效果。结果:观察组治愈率更高,并发症率更低,时间指标更少,与对照组差异明显(P<0.05);治疗前,两组血清β-HCG无明显差异(P>0.05),治疗后1周、2周、4周,观察组更低,与对照组差异显著(P<0.05);治疗前,两组孕酮与包块直径无明显差异(P>0.05),治疗后观察组孕酮与包块直径小于对照组(P<0.05)。结论:与甲氨蝶呤治疗EP比较,联合米非司酮方案,可提高疗效,且更好地促进血清β-hCG、孕酮水平下降,同时促进包块直径减小,但不会明显增加并发症风险,即疗效可靠,安全性好,值得应用。
Objective:To investigate the effect of combined methotrexate and mifepristone regimen on serumβ-HCG and complications in ectopic pregnancy(EP).Methods:Seventy-eight patients with EP were divided into two groups by two-color ball method,including control group(methotrexate treatment,n=39)and observation group(methotrexate+mifepristone treatment,n=39),admitted in June 2017—2021 June.Contrast effect.Results:The cure rate was higher,the complication rate was lower and the time index was less in the observation group,which was significantly different from the control group(P<0.05).Before treatment,there was no significant difference in serumβ-HCG between the two groups(P>0.05),but the serumβ-HCG in the observation group was lower than that in the control group at 1,2 and 4 weeks after treatment(P<0.05).Before treatment,there was no significant difference in the diameter of progesterone and mass between the two groups(P>0.05),and after treatment,the diameter of progesterone and mass in the observation group was smaller than that in the control group(P<0.05).Conclusion:Compared with methotrexate in EP treatment,combined mifepristone regimen can improve the efficacy,and better promote the reduction of serumβ-HCG and progesterone levels,while promoting the reduction of lump diameter,but does not significantly increase the risk of complications,that is,the efficacy is reliable,good safety,and worthy of application.
作者
吴秋霞
王琼
蔡淑寒
Wu Qiuxia(Department of Obstetrics and Gynecology,Neikeng Town Health Center,Jinjiang 362261)
出处
《黑龙江医药》
CAS
2023年第6期1266-1269,共4页
Heilongjiang Medicine journal
基金
2020年度佛山市卫生健康局医学科研课题立项(项目编号:20200034)。