健康管理模式联合二甲双胍对多囊卵巢综合征患者减重效果和妊娠率的相关性研究

Correlation Study on the Effects of Health Management Model Combined with Metformin on Weight Loss and Pregnancy Rate in Patients with Polycystic Ovary Syndrome

目的:探讨多囊卵巢综合征(PCOS)患者经过健康管理模式与二甲双胍联合干预对减重效果的影响,并分析与妊娠率的相关性。方法:收集我院生殖不孕门诊于2022年1月—2022年12月就诊的60例PCOS不孕患者,依照随机数字表法分为对照组(30例)与观察组(30例),对照组给予常规干预,观察组基于对照组方案施行二甲双胍片配合健康管理模式的干预方案,两组均连续干预3~6个月。比较两组体重、体重指数、腰臀比、内分泌激素、血糖及胰岛素水平、卵泡发育监测情况及妊娠率。结果:两组体重、BMI、WHR,血清T、E2、LH、PRL水平,血清FPG、FINS、HOMA-IR水平干预后均较干预前减低,且观察组指标均较对照组低,有统计学差异(P<0.05)。两组子宫内膜厚度、成熟卵泡个数干预后均较干预前增加,且观察组子宫内膜厚度、成熟卵泡个数高于对照组,有统计学差异(P<0.05)。干预后,观察组排卵率、妊娠率均较对照组的高,而早孕流产率较对照组低,有统计学差异(P<0.05)。结论:PCOS不孕患者通过健康管理模式与二甲双胍联合干预,可有效减重,增加排卵率、妊娠率,改善妊娠结局;且还可改善胰岛素抵抗,调节内分泌激素、血糖及胰岛素水平;辅助患者改善其不良健康行为,促其能遵从健康的生活方式,使其长期获益,具有良好的应用前景和推广意义。

Objective:To investigate the effect of health management mode combined with metformin on weight loss in patients with polycystic ovary syndrome(PCOS),and to analyze the correlation with pregnancy rate.Methods:Sixty patients with PCOS infertility treated in the fertility and infertility clinic of our hospital from January 2022 to December 2022 were collected and divided into control group(30 cases)and observation group(30 cases)according to random number table method.The control group received routine intervention,and the observation group received metformin tablets combined with health management mode intervention based on the control group plan.Both groups were subjected to continuous intervention for 3-6 months.Body weight,body mass index,waist-to-hip ratio,endocrine hormones,blood glucose and insulin levels,follicle development monitoring and pregnancy rate were compared between the two groups.Results:Body weight,BMI,WHR,serum T,E2,LH,PRL levels,serum FPG,FINS and HOMA-IR levels in both groups were lower after intervention than before intervention,and the indexes in the observation group were lower than those in the control group,with statistical difference(P<0.05).The endometrial thickness and the number of mature follicles in both groups increased after intervention,and the endometrial thickness and the number of mature follicles in the observation group were higher than those in the control group,with statistical differences(P<0.05).After the intervention,the ovulation rate and pregnancy rate of the observation group were higher than that of the control group,while the early pregnancy abortion rate was lower than that of the control group,with statistical difference(P<0.05).Conclusion:Health management mode combined with metformin can effectively reduce weight,increase ovulation rate and pregnancy rate,and improve pregnancy outcome in PCOS infertility patients.It can also improve insulin resistance,regulate endocrine hormones,blood sugar and insulin levels;Assisting patients to improve their bad health behaviors,promoting them to follow a healthy lifestyle,and making them benefit for a long time has a good application prospect and popularization significance.