中性粒细胞、淋巴细胞及其比值对间歇期痛风患者FEUA分期的评估价值研究

Evaluation Value of Neutrophils,Lymphocytes,and Their Ratios in FEUA Staging of Intermittent Gout Patients

目的探讨中性粒细胞、淋巴细胞及其比值对间歇期痛风患者尿酸排泄分数(FEUA)分期的评估价值。方法选取2019年3月~2022年3月在我院门诊就诊的69例间歇期痛风患者进行研究。所有研究对象均完成血尿酸(UA)、肌酐(Cr)及24h尿液检查[24h尿尿酸、24h尿量、24h尿肌酐],计算其FEUA,依据FEUA分期将患者分为排泄减少组(n=50,FEUA<7%)、混合组(n=10,7%≤FEUA≤12%)、生长增多组(n=9,FEUA>12%)。比较3组患者的24h尿尿酸、24h尿量、24h尿肌酐、血UA、Cr、中性粒细胞、淋巴细胞及其比值。使用受试者工作特征(ROC)曲线分析中性粒细胞/淋巴细胞对不同FEUA分期间歇期痛风患者的评估价值。结果3组患者间年龄、性别、体质量、吸烟、饮酒、受累关节数量、家族遗传史、高血压、糖尿病等一般资料比较无统计学意义(P>0.05);3组患者间24h尿肌酐、淋巴细胞计数比较无统计学意义(P>0.05),3组患者间24h尿尿酸、24h尿量、血UA、Cr、中性粒细胞计数、中性粒细胞/淋巴细胞比值比较存在统计学意义(P<0.05)。ROC曲线分析显示,中性粒细胞/淋巴细胞比值诊断排泄减少期痛风、混合期痛风、生长增多期痛风具有一定评估价值。结论中性粒细胞、淋巴细胞及其比值对间歇期痛风患者FEUA分期具有一定评估价值。

Objective To explore the evaluation value of neutrophils,lymphocytes,and their ratios in the staging of uric acid excretion fraction(FEUA)in patients with intermittent gout.Method A study was conducted on 69 patients with intermittent gout who visited our outpatient department from March 2019 to March 2022.All study subjects completed blood uric acid(UA),creatinine(Cr),and 24-hour urine tests[24-hour urine uric acid,24-hour urine volume,24-hour urine creatinine],and calculated their FEUA.According to the FEUA staging,patients were divided into a reduced excretion group(n=50,FEUA<7%),a mixed group(n=10,7%≤FEUA≤12%),and an increased growth group(n=9,FEUA>12%).Compare the 24-hour urine uric acid,24-hour urine output,24-hour urine creatinine,blood UA,Cr,neutrophils,lymphocytes,and their ratios among three groups of patients.The evaluation value of neutrophils/lymphocytes in patients with intermittent gout at different FEUA stages using the receiver operating characteristic(ROC)curve analysis.Results There was no significant difference in age,sex,body mass,smoking,drinking,number of involved joints,family genetic history,hypertension,diabetes and other general information among the three groups(P>0.05);There was no statistically significant difference in 24-hour urine creatinine and lymphocyte count among the three groups of patients(P>0.05),while there was a statistically significant difference in 24-hour urine uric acid,24-hour urine volume,blood UA,Cr,neutrophil count,and neutrophil/lymphocyte ratio among the three groups of patients(P<0.05).ROC curve analysis shows that the neutrophil/lymphocyte ratio has certain evaluation value in diagnosing gout in the reduced excretion stage,mixed stage,and increased growth stage.Conclusion Neutrophils,lymphocytes,and their ratios have certain evaluation value for FEUA staging in intermittent gout patients.