洁白丸联合莫沙必利治疗功能性消化不良的临床研究

Clinical study on Jiebai Pills combined with Mosapride Citrate Tablets in treatment of functional dyspepsia

目的 探讨洁白丸联合枸橼酸莫沙必利片治疗功能性消化不良的临床疗效。方法 回顾性分析2022年2月—2023年2月在武汉市中西医结合医院治疗的94例功能性消化不良患者的临床资料。根据用药种类的不同分为对照组和治疗组,每组各47例。对照组餐前口服枸橼酸莫沙必利片,5 mg/次,3次/d;治疗组在对照组治疗基础上餐前口服洁白丸,0.8 g/次,3次/d。两组患者经14 d治疗。观察两组患者临床疗效,比较治疗前后两组患者症状改善时间,SID评分、NDI评分、PSQI评分和FDDQL评分,血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)和降钙素基因相关肽(CGRP)水平,及胃肠激素指标胃动素(MTL)、胃蛋白酶原Ⅰ(PGI)、胃蛋白酶原Ⅱ(PGII)和胃泌素(GAS)水平。结果 治疗后,治疗组临床有效率(97.87%)明显高于对照组(80.85%,P<0.05)。治疗后,治疗组症状改善时间均明显早于对照组(P<0.05)。治疗后,两组患者SID评分明显降低,而NDI评分、PSQI评分和FDDQL评分均较治疗前显著升高(P<0.05),且治疗组评分改善程度比对照组更显著(P<0.05)。治疗后,两组血清CRP、IL-6、IL-10和TNF-α水平明显降低,而CGRP、MTL、PGI、PGII和GAS水平明显升高(P<0.05),且治疗组明显好于对照组(P<0.05)。结论 洁白丸联合枸橼酸莫沙必利片治疗功能性消化不良可有效改善临床症状,降低机体炎症反应,促进胃肠动力,促进患者生活质量及睡眠质量提高。

Objective To explore the clinical efficacy of Jiebai Pills combined with Mosapride Citrate Tablets in treatment of functional dyspepsia.Methods The clinical data of patients(94 cases)with functional dyspepsia in Wuhan Hospital of Traditional Chinese and Western Medicine from February 2022 to February 2023 were analyzed retrospectively.They were randomly divided into control and treatment group,and each group had 47 cases.Patients in the control group were po administered with Mosapride Citrate Tablets before meal,5 mg/time,three times daily.Patients in the treatment group were po administered with Jiebai Pills on the basis of the control group,0.8 g/time,three times daily.Patients in two groups were treated for 14 d.After treatment,the clinical evaluation was evaluated,and the improvement time of symptom,the scores of SID,NDI,PSQI and FDDQL,the levels of CRP,IL-6,IL-10,TNF-αand CGRP,and the levels of gastrointestinal hormone indicators MTL,PGI,PGII and GAS in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group(97.87%)was significantly higher than that of the control group(80.85%,P<0.05).After treatment,the improvement time of symptom in the treatment group was significantly earlier than that in the control group(P<0.05).After treatment,the SID score was significantly decreased,while the NDI score,PSQI score and FDDQL score were significantly increased in two groups(P<0.05),and the improvement of score in the treatment group was more significant than that in the control group(P<0.05).After treatment,the serum levels of CRP,IL-6,IL-10 and TNF-αwere significantly decreased,while the levels of CGRP,MTL,PGI,PGII and GAS were significantly increased in two groups(P<0.05),and these indicators in the treatment group was significantly better than those in the control group(P<0.05).Conclusion Jiebai Pills combined with Mosapride Citrate Tablets in treatment of functional dyspepsia can effectively improve clinical symptoms,reduce inflammatory reaction,promote gastrointestinal motility,and improve the quality of life and sleep of patients.