植物NLR免疫受体的结构、生化功能及分子调控

Structure,biochemical function and molecular regulation of plant NLRs

NLR受体是植物免疫中重要的抗病蛋白,植物体在应对病原微生物入侵时需要激活NLR受体以触发免疫反应。随着功能基因组学、结构生物学技术的快速发展, NLR受体蛋白的结构功能以及激活机制取得了极大的进展,尤其是抗病小体结构的精密解析。本文综述了NLR受体蛋白的结构类型,并阐述了NLR受体对病原微生物效应蛋白的识别方式、NLR受体的激活机制以及分子调控模式,以期为今后的植物抗病免疫研究提供参考依据。

NLR receptors are important disease resistance proteins in plant immunity.Plants need to activate NLR receptors in response to pathogenic microbial invasion to trigger immune responses.With the rapid development of functional genomics and structural biology technologies,great progress has been made in the structure,function and activation mechanism of NLR receptors,especially in the sophisticated resolution of the structure of resistosome.In this paper,we review the structure of NLR protein,and describe its recognition pattern,activation mechanism and molecular regulation mode of NLR receptors to pathogen effectors,in order to provide a reference for broadening the research direction of plant immunity.