阻塞性睡眠呼吸暂停发病的上气道扩张肌机制及对策

Mechanism of upper airway muscles in the pathogenesis of obstructive sleep apnea and potential therapeutic strategy

阻塞性睡眠暂停低通气综合征是一种常见的睡眠障碍,可引起全身多系统损害,已成为重大的公共卫生负担之一;探索不同病理生理机制亚型的个体化治疗迫在眉睫,其中上气道扩张肌功能障碍是主要发病机制之一。本文综述上气道肌肉功能障碍在阻塞性睡眠呼吸暂停发病机制中的作用及相关治疗方法研究进展,为进一步探索针对性治疗策略提供新思路。

Obstructive sleep apnea-hypopnea syndrome(OSAHS)is a prevalent sleep disorder associated with multiple systemic health issues and has emerged as a major public health concern.It is critical to investigate personalized treatments for different subtypes based on distinct pathophysiological mechanisms.Upper airway muscle dysfunction is recognized as one of the key factors in the development of OSAHS.This article provided a comprehensive review of the various mechanisms and therapeutic approaches related to the upper airway dilator muscles in OSAHS,and proposed an innovative treatment strategy for this condition.