嗅觉刺激偏头痛患者的脑功能磁共振成像初步研究

A preliminary study of odor-induced task functional magnetic resonance imaging in migraine patients

目的观察偏头痛患者在嗅觉刺激下的脑功能磁共振成像(fMRI)变化,分析其嗅觉相关脑网络特征。方法收集2021年1月至2022年1月在川北医学院附属医院神经内科门诊确诊的27例偏头痛患者,同期招募20名健康成年人作为对照组。收集所有受试者的人口学和临床特征资料。对所有受试者在嗅觉任务刺激下行同步fMRI扫描,使用SPM12、Matlab2019b软件进行磁共振图像数据处理,并结合SPSS 23.0软件进行统计学分析。结果对照组激活脑区包括左侧小脑、左侧颞下回、左侧梭状回、右侧额中回、右侧中央前回、脑岛、右侧中央沟盖、缘上回、右侧豆状壳核、中扣带回、中央旁小叶、顶上回(P<0.05)。偏头痛组激活脑区包括左侧小脑、右侧梭状回、右侧颞下回、右侧中央前回、右侧中央后回(P<0.05)。两组相比,偏头痛组在右侧岛叶、右侧额中回眶部、左侧额下回眶部、右侧背外侧额上回、右侧颞上回、右侧枕上回、内侧和旁扣带脑回、右侧顶上回的激活强度弱于对照组(P<0.05)。结论偏头痛患者有多个脑区参与嗅觉处理,存在特殊性的嗅觉相关脑网络。

Objective To observe the changes in brain functional magnetic resonance imaging(fMRI)in migraine patients under olfactory stimuli and analyze the characteristics of olfactory-related brain networks.Methods Twenty-seven migraine patients(migraine group)enrolled in the Department of Neurology,Affiliated Hospital of North Sichuan Medical College from January 2021 to January 2022 were included,and 20 healthy adults were recruited as control group during the same period.All subjects underwent synchronous fMRI scanning under olfactory task stimulation,and magnetic resonance imaging data processing was performed using SPM12 and Matlab2019b softwares,and statistical analysis was performed with SPSS 23.0 software.Results The activated brain regions in the control group included the left cerebellum,left inferior temporal gyrus,left fusiform gyrus,right middle frontal gyrus,right anterior central gyrus,insula,right central sulcus,superior marginal gyrus,right lenticular putamen,middle cingulate gyrus,paracentral lobule,and superior parietal gyrus(P<0.05).The activated brain regions in the migraine group included the left cerebellum,right fusiform gyrus,right inferior temporal gyrus,right anterior central gyrus,and right posterior central gyrus(P<0.05).Compared with the control group,the activation intensity of the migraine group was weaker in the right insula,right middle frontal gyrus orbit,left inferior frontal gyrus orbit,right dorsolateral superior frontal gyrus,right superior temporal gyrus,right superior occipital gyrus,medial and paracingulate gyrus,and right superior parietal gyrus(P<0.05).Conclusion Migraine patients have multiple brain regions involved in olfactory processing and have specific olfactory-related brain networks.