大青龙汤加味治疗小儿甲型流行性感冒表寒里热证30例临床观察

Clinical observation on 30 cases of infantile type A influenza with exterior cold and interior heat syndrome treated with modified Daqinglong Tang(大青龙汤)

目的观察大青龙汤加味治疗小儿甲型流行性感冒(简称“流感”)表寒里热证的临床疗效。方法选取2022年5—8月浏阳市中医医院儿科治疗的90例甲型流感表寒里热证患儿,采用回顾性研究方法分为西医组、中医组、中西医结合组,各30例。西医组采用磷酸奥司他韦颗粒口服治疗,中医组采用大青龙汤加味治疗,中西医结合组在西医组治疗方法的基础上予以大青龙汤加味治疗。3组均治疗3 d后统计疗效。结果中医组显效率为63.33%(19/30),显著高于西医组的53.33%(16/30)和中西医结合组的53.33%(16/30),差异有统计学意义(P<0.05);3组总有效率均为100.0%(30/30),差异无统计学意义(P>0.05)。3组治疗前后发热、咽痛、鼻塞、流涕症状积分差值比较,差异均无统计学意义(P>0.05)。中医组恶寒症状治疗前后积分差值显著高于西医组,差异有统计学意义(P<0.05);西医组与中西医结合组恶寒症状差值比较,差异无统计学意义(P>0.05)。中医组、中西医结合组头痛、肢体酸痛症状评分差值显著高于西医组,差异有统计学意义(P<0.05);中医组与中西医结合组恶寒、头痛、肢体酸痛症状评分差值比较,差异无统计学意义(P>0.05)。结论大青龙汤加味治疗小儿甲型流感表寒里热证疗效满意,可显著改善头痛、肢体酸痛症状,提高患儿舒适度,值得临床推广应用。

Objective To observe the clinical efficacy of modified Daqinglong Tang(大青龙汤)in the treat⁃ment of infantile type A influenza with exterior cold and interior heat syndrome.Methods 90 children with exterior cold and interior heat syndrome of influenza A treated in the pediatric department of Liuyang Traditional Chinese Medicine Hospital from May 2022 to August 2022 were selected and divided into a Western medicine group,a Chi⁃nese medicine group,and a group combining Chinese and Western medicine by retrospective methods,with 30 cases in each group.The Western medicine group received oral treatment with oseltamivir phosphate granules,the Chinese medicine group received treatment with Daqinglong Tang,and the combining Chinese and Western medicine group received treatment with Daqinglong Tang on the basis of the Western medicine group’s treatment method.Af⁃ter 3 days,all 3 groups were statistically analyzed for efficacy.Results The apparent efficiency of the traditional Chinese medicine group was 63.33%(19/30),significantly higher than 53.33%(16/30)in the Western medicine group and 53.33%(16/30)in the combining Chinese and Western medicine group,with a statistically significant difference(P<0.05).The total effective rate of all three groups was 100.0%(30/30),with no statistically signifi⁃cant difference(P>0.05).There was no statistically significant difference in the scores of fever,sore throat,nasal congestion,and runny nose symptoms between the three groups before and after treatment(P>0.05).The difference in integral scores between the Chinese medicine group and the Western medicine group before and after treatment for aversion to cold symptoms was significantly higher,with a statistically significant difference(P<0.05).There was no statistically significant difference(P>0.05)in the scores of cold aversion symptoms between the Western medi⁃cine group and the combining of Chinese and Western medicine group.The difference in scores of headache and limb soreness symptoms between the traditional Chinese medicine group and the combining of traditional Chinese and Western medicine group was significantly higher than that of the Western medicine group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the scores of headache and limb soreness between the traditional Chinese medicine group and the combining of traditional Chinese and Western medicine group(P>0.05).Conclusion Modified Daqinglong Tang has a satisfactory therapeutic effect on children with type A influenza of exterior cold and interior heat syndrome,can significantly improve headache and limb pain symptoms,and improve children’s comfort,which is worthy of clinical popularization.