化湿理气止痛汤加减治疗小儿功能性腹痛邪滞肠络证30例临床观察

Clinical observation on the treatment of 30 cases of functional abdominal pain in children with pathogenic stagnation of intestinal meridian syndrome with modified Huashi Liqi Zhitong Tang(化湿理气止痛汤)

目的观察化湿理气止痛汤加减治疗小儿功能性腹痛(FAP)邪滞肠络证的临床疗效。方法选取2019年1—12月于江苏省中医院儿科门诊治疗的60例FAP邪滞肠络证患儿,按照随机数字表法分为对照组和治疗组,各30例。对照组予理气和胃口服液口服,治疗组予化湿理气止痛汤加减口服,2组均连续治疗4周并随访1个月后统计疗效。结果治疗前,2组的主症积分、次症积分和总积分比较,差异无统计学意义(P>0.05),具有可比性;治疗2周后,2组的主症积分、次症积分和总积分均较同组治疗前显著降低,差异均有统计学意义(P<0.05),且治疗组降低更显著(P<0.05);治疗4周及治疗后1个月,2组的主症积分、次症积分和总积分均较同组治疗2周后显著降低,差异均有统计学意义(P<0.05),但2组间比较及治疗后1个月与同组治疗4周比较,差异均无统计学意义(P>0.05)。治疗2周后,治疗组的总有效率和愈显率分别为83.33%(25/30)和33.33%(10/30),对照组分别为50.00%(15/30)和13.33%(4/30),2组比较,差异均有统计学意义(P<0.05)。治疗4周和治疗后1个月,2组的总有效率和愈显率比较,差异均无统计学意义(P>0.05)。结论化湿理气止痛汤加减治疗小儿FAP邪滞肠络证,可显著改善临床症状,明显缩短病程,且疗效确切,值得临床推广应用。

Objective To observe the clinical efficacy of modified Huashi Liqi Zhitong Tang(化湿理气止痛汤)in the treatment of functional abdominal pain with pathogenic stagnation of intestinal meridian syndrome.Meth⁃ods Sixty cases of functional abdominal pain in children with intestinal obstruction syndrome who were treated at the pediatric outpatient department of Jiangsu Province Chinese Medicine Hospital from January 2019 to December 2019 were divided into a control group and a treatment group in a random number table,with 30 cases in each group.The control group was treated with Liqi Hewei oral liquid,while the treatment group with modified Huashi Liqi Zhitong Tang orally.Both groups were treated continuously for 4 weeks and followed up for 1 month before sta⁃tistical treatment.Results Before treatment,there was no statistically significant difference in the main symptom score and total score between the two groups(P>0.05),indicating comparability.After 2 weeks of treatment,the main symptom score and total score of the two groups were significantly reduced compared to the same group before treatment,with statistical significance(P<0.05),and the decrease was more significant in the treatment group(P<0.05).After 4 weeks of treatment and 1 month after treatment,the main symptom score and total score of the two groups were significantly reduced compared to the same group after 2 weeks of treatment,with statistical signifi⁃cance(P<0.05).However,there was no statistically significant difference(P>0.05)between the two groups and between the two groups after 1 month of treatment and the same group after 4 weeks of treatment.Before treatment,there was no statistically significant difference in the sub symptom scores between the two groups(P>0.05),indica⁃ting comparability.After 2 weeks of treatment,the sub symptom scores of both groups were significantly reduced compared to before treatment in the same group,with statistically significant differences(P<0.05),and the decrease was more significant in the treatment group(P<0.05).After 4 weeks of treatment and 1 month of treatment,the sub symptom scores of both groups were significantly reduced compared to the same group after 2 weeks of treatment,with statistical significance(P<0.05).However,there was no statistical significance(P>0.05)in the comparison between the two groups and between the same group after 1 month of treatment and 4 weeks of treatment.After 2 weeks of treatment,the total effective rate and recovery or improvement rate of the treatment group were 83.33%(25/30)and 33.33%(10/30),respectively,while the control group was 50.00%and 13.33%,respectively.The difference between the two groups was statistically significant(P<0.05).After 4 weeks of treatment and 1 month af⁃ter treatment,there was no statistically significant difference in the total effective rate and recovery or improvement rate between the two groups(P>0.05).Conclusion Modified Huashi Liqi Zhitong Tang can significantly improve clinical symptoms,shorten the course of the disease,and have a definite therapeutic effect in the treatment of function⁃al abdominal pain with pathogenic stagnation of intestinal meridian syndrome.It is worthy of clinical popularization.