不同因素和苯暴露情况对劳动者谷丙转氨酶影响的交互作用分析

Interaction analysis of the influence of different factors and benzene exposure on workers'alanine aminotransferase

目的:探讨苯暴露劳动者谷丙转氨酶(ALT)的主要影响因素。方法:于2022年6月,收集2021年天津市613家存在苯危害企业和585家存在非苯危害企业资料,共收集13 018名苯暴露劳动者和13 018名非苯暴露劳动者职业健康检查资料,分析用人单位所属地区、企业类型、行业分类和企业规模情况,以及苯暴露和非苯暴露劳动者职业健康检查资料。用相加交互作用评估个人一般情况、职业史、企业信息与苯暴露情况对ALT的影响。结果:不同个人一般情况、职业史、企业信息苯暴露劳动者出现ALT异常的风险均高于非苯暴露的劳动者,差异均有统计学意义( P<0.05)。相加交互作用的定量分析发现,性别( RERI为2.632,95% CI:1.966~3.297;AP为0.383,95% CI:0.311~0.456;S为1.813,95% CI:1.530~2.149)、年龄( RERI为1.142,95% CI:0.928~1.356;AP为0.462,95% CI:0.371~0.552;S为4.461,95% CI:1.800~11.053)、工龄( RERI为-1.199,95% CI:-1.653~-0.745;AP为-0.456,95% CI:-0.640~-0.271;S为0.576,95% CI:0.479~0.693)、所属地区( RERI为0.421,95% CI:0.148~0.694;AP为0.161,95% CI:0.053~0.268;S为1.350,95% CI:1.057~1.726)、行业分类( RERI为0.627,95% CI:0.345~0.910;AP为0.232,95% CI:0.132~0.332;S为1.584,95% CI:1.233~2.035)和苯暴露对血清ALT异常情况的相加交互作用有统计学意义。 结论:应重点关注石油化工行业、油储及运输、电力生产中年龄小于40岁的男性劳动者,更有针对性地保护劳动者的身体健康,减少因病致残的风险。

ObjectiveTo investigate the main factors that influence ALT abnormalities in workers exposed to benzene.MethodsIn June 2022,data of 613 enterprises with benzene hazards and 585 enterprises with non-benzene hazards in Tianjin in 2021 were collected,and occupational health examination data of 13018 workers with benzene exposure and 13018 workers with non-benzene exposure were collected,and the region,enterprise type,industry classification and enterprise scale of the employer were analyzed.And occupational health examination data of workers with benzene exposure and non-benzene exposure.The effects of personal general situation,occupational history,enterprise information and benzene exposure on alanine aminotransferase were evaluated by additive interaction.ResultsCompared with the group of non-benzene-exposed workers,the personal general conditions,occupational history,company information were higher in the benzene-exposed workers,and the differences were statistically significant(P<0.05).The quantitative analysis of additive interaction found that gender(RERI=2.632,95%CI:1.966-3.297;AP=0.383,95%CI:0.311-0.456;S=1.813,95%CI:1.530-2.149),age(RERI=1.142,95%CI:0.928-1.356;AP=0.462,95%CI:0.371-0.552;S=4.461,95%CI:1.800-11.053),length of service(RERI=-1.199,95%CI:-1.653--0.745;AP=-0.456,95%CI:-0.640--0.271;S=0.576,95%CI:0.479-0.693),region(RERI=0.421,95%CI:0.148-0.694;AP=0.161,95%CI:0.053-0.268;S=1.350,95%CI:1.057-1.726),industry classification(RERI=0.627,95%CI:0.345-0.910;AP=0.232,95%CI:0.132-0.332;S=1.584,95%CI:1.233-2.035)and benzene exposure had a statistically significant additive interaction with abnormal serum ALT.ConclusionEmphasis should be placed on male workers under the age of 40 in the petrochemical industry,oil storage and transportation,and power production,so as to protect the health of workers more specifically and reduce the risk of disability due to disease.