急性重症亚硝酸盐中毒并发大面积肺血栓栓塞症1例

One case of acute severe nitrite poisoning with massive pulmonary thromboembolism

本文报道急性重症亚硝酸盐中毒并发大面积肺血栓栓塞症(PTE)1例,结合文献探讨其发病机制,总结治疗经验。亚硝酸盐中毒常见症状包括头痛、腹痛、气促、紫绀等,可继发脑病、神经功能障碍、溶血等,而并发PTE的病例在临床中较为罕见,容易发生漏诊。亚硝酸盐、高铁血红蛋白可能导致血管内皮受损,促进血栓形成,对于急性重症亚硝酸盐中毒患者的诊治中应采取针对性预防措施。

This paper reported a case of acute severe nitrite poisoning with massive pulmonary thromboembolism(PTE),discussed the pathogenesis and summarized the treatment experience.Common symptoms of nitrite poisoning include headache,abdominal pain,shortness of breath,cyanosis,etc.,which can be followed by encephalopathy,neurological dysfunction,hemolysis,etc.However,the cases of PTE are rare in clinical practice and are prone to missed diagnosis.Nitrite and methemoglobin may lead to vascular endothelial damage and promote thrombosis.In the diagnosis and treatment of acute severe nitrite poisoning patients,the targeted preventive measures should be taken.