接触消毒剂与慢性阻塞性肺疾病的研究进展

Research progress on exposure to disinfectants and chronic obstructive pulmonary disease

慢性阻塞性肺疾病(COPD)是常见的慢性呼吸道疾病。近年来,COPD累积患病率不断升高,与之发生相关的病因及诱发因素较多,职业性有害因素在其中发挥重要作用。接触消毒剂及其产物与气道炎症、呼吸道症状以及COPD发生之间存在关联。新型冠状病毒肺炎(COVID-19)疫情期间,消毒成为防控的重要环节,消毒剂的使用率明显增加。因此,本综述通过总结消毒剂及其产物对COPD的影响,并且讨论可能的发生机制,根据消毒剂的发展现状提出合理使用消毒剂的建议。

Chronic obstructive pulmonary disease(COPD)is a common chronic respiratory disease.In recent years,the cumulative prevalence of COPD has been increasing.There are many etiologies and predisposing factors related to COPD,among which occupational risk factors play an important role.Recent studies have found an association between exposure to disinfectants and their products and airway inflammation,respiratory symptoms,and the development of COPD.During the period of COVID-19,disinfection has become an important link in the prevention and control of COVID-19,and the use rate of disinfectants has increased significantly.Therefore,this review summarizes the effects of disinfectants and their products on COPD,discusses the possible mechanisms,and puts forward suggestions for rational use of disinfectants according to the current situation and the development status of disinfectants.