CXCR3及其配体在儿童心血管疾病中的研究进展

Advances in CXCR3 and its ligand in pediatric cardiovascular disease

趋化因子受体3(chemokine receptor 3, CXCR3)属于CXC亚趋化因子, 主要表达于活化的T细胞、B细胞和NK细胞表面, 与其特异性趋化因子配体CXCL9、CXCL10、CXCL11、CXCL4结合, 引起靶细胞的定向迁移和免疫反应, 在内皮细胞功能调节、血管生成和抑制方面有重要作用。研究发现, CXCR3及其配体通过炎症趋化、调节血管功能、抑制纤维化等多种作用方式参与儿童心血管疾病的发生进展, 是心力衰竭、川崎病、高血压等多种心血管疾病新兴的重要生物标志物, 有望成为儿童心血管疾病治疗的新靶点。该文主要阐述CXCR3及其配体在儿童心血管疾病中的功能及机制, 以期为儿童心血管疾病药物开发提供新思路。

Chemokine receptor 3(CXCR3),a sub chemokine of CXC,is mainly expressed on the surface of activated T cells,B cells and NK cells,and its specific chemokine ligands CXCL9,CXCL10,CXCL11,CXCL4 can induce targeted migration and immune response of target cells,which plays an important role in endothelial cell function,angiogenesis and inhibition.CXCR3 and its ligands have been found to be involved in the progression of cardiovascular diseases in children through various mechanisms including inflammatory chemotaxis,regulation of vascular function and inhibition of fibrosis.They are emerging important biomarkers for various cardiovascular diseases such as heart failure,Kawasaki disease,and hypertension,and are expected to become new targets for the treatment of cardiovascular diseases in children.This article reviews the functions and mechanisms of CXCR3 and its ligands in childhood cardiovascular diseases,in order to provide new ideas for drug development of childhood cardiovascular diseases.