维生素K与儿童骨代谢的研究进展

Advances in vitamin K and bone metabolism in children

天然存在的维生素K(vitamin K, VK)包括维生素K1(vitamin K1, VK1)和维生素K2(vitamin K2, VK2)两种形式。VK功能与其侧链数目有关, 除了参与凝血功能以外, VK还逐渐被发现参与人体骨代谢, 与成人骨质疏松症的发生密切相关。儿童期生长发育迅速, 是骨代谢极其旺盛的时期, VK在儿童骨代谢性疾病中的作用近几年逐渐被认识, 但对不同年龄儿童VK的水平及VK参与儿童骨代谢性疾病的机制研究仍较少。该文将从VK的种类及代谢、VK调节骨代谢的机制、VK的水平及其在骨代谢疾病中作用的研究现状等方面综述, 以期为儿童骨骼健康的防治提供新的认识和思路。

Vitamin K(VK)occurs naturally in two forms,including vitamin K1(VK1)and vitamin K2(VK2).The function of VK is related to the number of its side chains.In addition to the function of coagulation,VK is also gradually found to be involved in bone metabolism,which is closely related to the occurrence of adult osteoporosis.The rapid growth and development in childhood is a period of extremely vigorous bone metabolism.The role of VK in children′s bone metabolic diseases has been gradually recognized in recent years.However,there are still few clinical studies on the level of VK in children of different ages and how VK participates in children′s bone metabolic diseases.This article reviews the types and metabolism of VK,the mechanism of VK regulating bone metabolism,the level of VK and its role in bone metabolic diseases,so as to provide new understanding and ideas for the prevention and treatment of bone health in children.