肥胖儿童青少年血清炎症因子与体成分相关性研究

Correlations between serum inflammatory factors and body composition in obese children and adolescents

目的探讨肥胖儿童青少年血清TNF-α、IL-6及hs-CRP与体成分的相关性。方法选取2020年4月至2022年1月在上海交通大学医学院附属新华医院临床营养科就诊的105例肥胖儿童青少年为研究对象, 检测其血清炎症因子(TNF-α、IL-6及hs-CRP)和体成分(腰臀比、腰围身高比、BMI、体脂肪、体脂百分比、去脂体重、去脂体重百分比、骨骼肌、骨骼肌百分比及肥胖度), 并根据血清炎症因子, 将研究对象分成TNF-α升高组(n=49)与正常组(n=56)、IL-6升高组(n=13)与正常组(n=92)和hs-CRP升高组(n=44)与正常组(n=61)。结果 TNF-α与体脂百分比呈正相关(r=0.224, P=0.022), 与去脂体重百分比呈负相关(r=-0.226, P=0.021)。IL-6与腰臀比、腰围身高比、BMI、体脂肪、体脂百分比及肥胖度呈正相关(r=0.197、0.370、0.303、0.257、0.325、0.348, 均P<0.05), 与去脂体重百分比及骨骼肌百分比呈负相关(r=-0.316、-0.223, 均P<0.05)。hs-CRP与BMI、体脂肪及肥胖度呈正相关(r=0.261、0.220、0.244, 均P<0.05), 与去脂体重百分比呈负相关(r=-0.194, P=0.047)。结论肥胖儿童青少年血清TNF-α、IL-6及hs-CRP与体成分存在相关性。

Objective To explore the correlations between serum TNF-α,IL-6,hs-CRP levels and body composition in obese children and adolescents.Methods A total of 105 obese children and adolescents attending the Department of Clinical Nutrition,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine from April 2020 to January 2022 were investigated for serum inflammatory factors(TNF-α,IL-6 and hs-CRP)and body composition(waist-to-hip ratio,waist-to-height ratio,BMI,body fat mass,percent body fat,fat free mass,percent of fat free mass,skeletal muscle mass,percent of skeletal muscle mass and obesity degree).And based on serum inflammatory factors,they were divided into elevated TNF-αgroup(n=49)and normal TNF-αgroup(n=56),elevated IL-6 group(n=13)and normal IL-6 group(n=92)and elevated hs-CRP group(n=44)and normal hs-CRP group(n=61),respectively.Results TNF-αwas positively correlated with percent body fat(r=0.224,P=0.022),while negatively correlated with percent of fat free mass(r=-0.226,P=0.021).IL-6 was positively correlated with waist-to-hip ratio,waist-to-height ratio,BMI,body fat mass,percent body fat,and obesity degree(r=0.197,0.370,0.303,0.257,0.325,0.348,all P<0.05),while negatively correlated with percent of fat free mass and percent of skeletal muscle mass(r=-0.316,-0.223,all P<0.05).And hs-CRP was positively correlated with BMI,body fat mass,and obesity degree(r=0.261,0.220,0.244,all P<0.05),while negatively correlated with percent of fat free mass(r=-0.194,P=0.047).Conclusion Serum TNF-α,IL-6 and hs-CRP may be correlated with body composition in obese children and adolescents.