特发性光线性皮肤病的光硬化治疗

Photohardening therapy for idiopathic actinic dermatoses

光硬化治疗为特发性光线性皮肤病的光疗和光化学疗法,其治疗目标是提高患者对日光的耐受,预防疾病发作,也称为光脱敏治疗。光硬化治疗的作用机制涉及多种细胞和炎症因子。该治疗手段适用于所有特发性光线性皮肤病,疗效肯定,安全性较好,因治疗特殊性导致依从性较差,但长波紫外线1快速硬化治疗和家庭光疗的兴起有望解决这一问题。

Photohardening therapy,also known as photodesensitization therapy,refers to the phototherapy and photochemotherapy of idiopathic actinic dermatoses,and its goal is to improve the patients′tolerance to sunlight and prevent disease flares.Its mechanisms of action involve a variety of cellular and inflammatory factors.This therapy is suitable for all idiopathic actinic dermatoses,with definite efficacy and good safety.However,the treatment specificity usually leads to poor compliance.The development of UVA1 rush hardening and home phototherapy is expected to solve this problem.