摘要
基因表观修饰在不改变DNA序列的情况下,能够开启或关闭基因信息表达的程序,其机制主要包括DNA甲基化、组蛋白修饰和miRNA调控。一系列研究显示,表观遗传调控参与特应性皮炎的发病。本文简要综述基因表观修饰在特应性皮炎发病机制中的作用。
Gene epigenetic modification can turn on and off the program of gene expression without changing the DNA sequence,and the underlying mechanisms mainly include DNA methylation,histone modification and miRNA regulation.A series of studies have shown that epigenetic regulation is involved in the pathogenesis of atopic dermatitis.This review briefly summarizes the role of gene epigenetic modification in the pathogenesis of atopic dermatitis.
作者
宋旷楠
张思平
Song Kuangnan;Zhang Siping(Wannan Medical College,Wuhu 241002,Anhui,China;Department of Dermatology,the First Affiliated Hospital of USTC(Anhui Provincial Hospital),Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,China)
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2023年第12期1167-1169,共3页
Chinese Journal of Dermatology
基金
安徽省自然科学基金(1808085MH259)。
关键词
皮炎
特应性
表观修饰
皮肤屏障
免疫细胞
Dermatitis
atopic
Epigenetic modification
Skin barrier
Immune cells
