肿瘤相关成纤维细胞在甲状腺癌增殖、侵袭与治疗中的作用

Role of cancer-associated fibroblasts in the proliferation,invasion,and treatment of thyroid cancer

甲状腺癌是最常见的内分泌恶性肿瘤之一。肿瘤相关成纤维细胞(cancer-associated fibroblasts,CAFs)是甲状腺癌肿瘤微环境中重要的细胞成分,其细胞起源、表型和功能均具有异质性。CAFs和肿瘤细胞之间的相互作用不断促进肿瘤的进展。CAFs可以通过改变胞外基质(extracellular matrix,ECM)结构功能、促进上皮向间充质转化(epithelial to mesenchymal tran⁃sition,EMT)和增强细胞因子分泌释放等方式,直接或间接促进甲状腺癌的发生发展。根据甲状腺癌中CAFs的特点目前已提出了一些可能的治疗策略。现结合文献对CAFs与甲状腺癌进展的研究进展进行综述。

Thyroid cancer is one of the most common endocrine malignancies.Cancer-associated fibroblasts(CAFs)are important cel⁃lular components in the tumor microenvironment of thyroid cancer,with heterogeneities in their cell origins,phenotypes,and functions.CAFs promote tumor progression through its interactions with tumor cells.CAFs can directly or indirectly promote the development and progression of thyroid cancer by altering the structure and function of the extracellular matrix,promoting epithelial-to-mesenchymal transition,and enhancing cytokine secretion and release.Based on the characteristics of CAFs in thyroid cancer,some possible treat⁃ment strategies have been proposed.This article reviews the research advances in CAFs and thyroid cancer progression based on the relevant literature.