基于肠道菌群探讨运动改善2型糖尿病的可能机制

Possible mechanisms of type 2 diabetes mellitus improvement via exerciseinduced changes in gut microbiota composition and metabolites

2型糖尿病(T2DM)是常见的慢性代谢性紊乱疾病,其发病机制尚无一致结论。随着微生态研究技术的革新,认为肠道菌群失调可能是T2DM的诱发原因之一。运动是糖尿病管理的有效手段之一,但其调节糖代谢的作用机制仍存在许多待解决的问题。近年来,人们发现运动可以改善肠道内环境和肠道菌群,本文将基于肠道菌群探讨运动对T2DM的影响,并对其机制研究进行综述,旨在为今后探究运动改善T2DM提供新思路。

Type 2 diabetes mellitus(T2DM)is a common chronic metabolic disease,while there is no consistent conclusion on the pathogenesis of T2DM.With the innovation of microecological research technology,intestinal dysbiosis is considered to be one of the causes of T2DM.Exercise is one of the effective means of diabetes management,while mechanism of regulating glucose metabo⁃lism still has many problems to be solved.In recent years,people have found that exercise can improve the intestinal environment and intestinal flora.This article will review the research on the influence and mechanism of exercise on T2DM based on intestinal flora,aiming to provide new ideas for exploring how exercise can improve T2DM in the future.