CD4^(+)T细胞在流感病毒感染诱发细胞因子风暴及急性肺损伤中的研究进展

Research progress of CD4^(+)T cells in influenza virus infection-induced cytokine storm and acute lung injury

CD4^(+)T细胞作为细胞免疫的主要武器,在控制和清除感染方面起着至关重要的作用,是机体抵抗感染性疾病的重要屏障。流感病毒感染引起的呼吸道感染性疾病具有极高的传染性、发病率及病死率,其感染机制较为复杂,尚未得到全面阐述。机体在流感病毒感染后诱发的旺盛免疫反应被称为“细胞因子风暴”,与过激的促炎细胞因子和广泛的组织损伤有关,最终可能导致急性肺损伤。因此,本文总结目前研究进展,重点阐述了CD4^(+)T细胞在流感病毒感染诱发细胞因子风暴的作用机制及急性肺损伤中的影响,为后续研究提供相关思路及理论指导,以期为流感病毒引起的疾病带来新的有效诊疗方法。

As the main weapon of cellular immunity,CD4^(+)T cells play a vital role in controlling and eliminating infections,and are an important barrier for the body to resist infections.Respiratory tract infectious diseases caused by influenza virus infection have extremely high infectivity,morbidity and mortality.The infection mechanism is relatively complicated and has not been fully ex⁃plained.The exuberant immune response induced by the body after influenza virus infection is described as a"cytokine storm"which is related to pro-inflammatory cytokines and tissue damage,which may eventually lead to acute lung injury.Therefore,this article sum⁃marizes the current research progress,focusing on the mechanism of CD4^(+)T cells in the cytokine storm induced by influenza virus in⁃fection and the impact of acute lung injury,providing relevant ideas and theoretical guidance for follow-up research,with a view to the disease caused by influenza virus bring new and effective methods of diagnosis and treatment.