线粒体功能障碍与卵巢早衰的研究进展

Research progress of mitochondrial dysfunction and premature ovarian failure

卵巢早衰(POF)是一种常见的生殖内分泌疾病,主要表现为因卵巢功能衰竭所致的提前闭经,严重影响女性健康。线粒体作为重要细胞器,不仅具有供能作用,还参与细胞分化、信息传递和凋亡等各种生命活动,其功能障碍与POF发生有关。笔者主要从线粒体能量代谢失衡、线粒体钙代谢失衡、线粒体DNA突变及线粒体动力学改变4个方面综述线粒体异常对POF的影响,并通过总结该疾病的相关机制,对POF的治疗方案作出相应见解及未来展望。

Premature ovarian failure(POF)is a common reproductive endocrine disorder that mostly appears as premature amenorrhea due to ovarian failure and has a significant negative impact on the health of women.As significant organelles,mitochondria play multiple roles in a variety of biological processes,including cell development,information transmission,and apoptosis,whose malfunction is thought to result in the occurrence of POF.The authors mainly investigate the consequences of mitochondrial abnormalities on POF from 4 viewpoints,namely,imbalanced mitochondrial energy metabolism,imbalanced mitochondrial calcium metabolism,mitochondrial DNA mutation,and mitochondrial dynamics changes.By outlining the disease′s pertinent mechanism,the treatment plan for POF is evaluated together with its future prospects.