CG、LAP与miR-155对妊娠期肝内胆汁淤积症的诊断价值及与疾病严重程度的关系

The diagnostic value of CG,LAP and miR-155 in intrahepatic cholestasis of pregnancy and relationship with disease severity

目的:探讨甘胆酸(CG)、亮氨酸氨基肽酶(LAP)与micro RNA-155(miR-155)对妊娠期肝内胆汁淤积症的诊断价值及与疾病严重程度的关系。方法:选取2018年11月至2023年3月六安世立医院收治的妊娠期肝内胆汁淤积症患者103例作为观察组,另选取同期在妇产科住院的非妊娠期肝内胆汁淤积症患者100例作为对照组,根据妊娠期肝内胆汁淤积症分度标准,将观察组患者分为重度组55例和轻度组48例。比较对照组患者和观察组、重度组和轻度组患者基础资料及CG、LAp、miR-155表达水平,分析CG、LAP与miR-155指标诊断妊娠期肝内胆汁淤积症及判定疾病严重程度的价值,并绘制ROC曲线。结果:观察组患者肝功能指标、CG、LAP与miR-155表达水平均高于对照组患者(P<0.05);重度组患者肝功能指标水平、CG、LAP与miR-155表达水平均高于轻度组(P<0.05);CG、LAP与miR-155联合检测诊断妊娠期肝内胆汁淤积症的AUC值高于单项检测(P<0.05),CG、LAP与miR-155联合检测评估妊娠期肝内胆汁淤积症严重程度的AUC值高于单项检测(P<0.05)。结论:检测CG、LAP与miR-155有助于早期诊断妊娠期肝内胆汁淤积症,且CG、LAP与MiR-155联合检测有助于早期预测妊娠期肝内胆汁淤积症的严重程度。

Objective:To investigate the diagnostic value of glycholic acid(CG),leucine aminopeptidase(LAP)and microRNA-155(miR-155)in intrahepatic cholestasis of pregnancy and their relationship with the severity of the disease.Methods:A total of 103 patients with intrahepatic cholestasis of pregnancy admitted to our hospital from November 2018 to March 2023 were selected as the observation group,and 100 patients with non-intrahepatic cholestasis of pregnancy admitted to the Department of Obstetrics and Gynecology during the same period were selected as the control group.According to the grading criteria of intrahepatic cholestasis of pregnancy,the patients were divided into a severe group(55 cases)and a mild group(48 cases).Basic data and levels of CG,LAP and miR-155 were compared between control group and observation group,severe group and mild group.The value of CG,LAP and miR-155 indexes in diagnosing intrahepatic cholestasis of pregnancy was analyzed and ROC curve was drawn.The value of CG,LAP and miR-155 indexes in determining the severity of the disease was analyzed and ROC curve was drawn.Results:Liver function indexes,CG,LAP and miR-155 levels in observation group were higher than those in control group(P<0.05).The levels of liver function indexes,CG,LAP and miR-155 in severe group were higher than those in mild group(P<0.05).The AUC value of CG,LAP and miR-155 combined test in the diagnosis of intrahepatic cholestasis of pregnancy was higher than that of single test(P<0.05),and the AUC value of CG,LAP and miR-155 combined test in the assessment of the severity of intrahepatic cholestasis of pregnancy was higher than that of single test(P<0.05).Conclusion:The detection of CG,LAP and miR-155 is helpful for early diagnosis of intrahepatic cholestasis of pregnancy,and the combined detection of CG,LAP and miR-155 is helpful for early prediction of the severity of intrahepatic cholestasis of pregnancy.