血脑屏障与脑小血管病相关研究进展

Research progress on the correlation between blood⁃brain barrier and cerebral small vessel disease

脑小血管病是脑卒中和血管性痴呆的常见病因,其潜在发病机制尚不清楚。病理学研究证实,血脑屏障损伤在脑小血管病发病机制中发挥重要作用。本文从影像学标志物、生物学标志物、病理生理学机制等方面对血脑屏障与脑小血管病相关研究最新进展进行综述,以为脑小血管病的诊断提供依据,并为其治疗提供潜在干预靶点。

Cerebral small vessel disease(CSVD)is a leading cause of stoke and vascular dementia,and its pathogenesis remains unclear.Research on brain histopathology has identified that the blood‑brain barrier plays a crucial role in the pathogenesis and progression of CSVD.This article reviews the research progress on the correlation between blood‑brain barrier and CSVD from imaging biomarkers,blood biomarkers and pathophysiology,to provide ideas for better diagnosis and treatment of CSVD.