儿童干燥综合征临床特点及其分类标准进展

Clinical characteristics and the progress of classification criteria for children with Sjögren′s syndrome

干燥综合征(SS)是一种慢性炎症性自身免疫性疾病,可分为原发性干燥综合征(pSS)、继发性干燥综合征(sSS)。儿童pSS与sSS具有相似临床特点,可用同一分类标准。与成人SS相比,儿童SS少发,起病隐匿,缺乏典型口、眼干燥的临床表现。故成人SS分类标准并不完全适用于儿童SS患者,但目前尚无广泛应用及得以验证的适用于儿童的分类标准,值得进一步探讨和研究。现就儿童SS的临床特点、分类诊断标准相关进展进行综述,并对儿童pSS与sSS进行比较。

Sjögren′s syndrome(SS)is a chronic inflammatory autoimmune disease,including primary SS(pSS)and secondary SS(sSS).Pediatric sSS has the similar clinical characters with pSS,which can be classified based on the same classification criteria.Compared with those of adult SS,pediatric SS is rare,insidious and lacks the typical manifestations of dry eyes and dry mouth.Therefore,the classification criteria for adult SS is not suitable for pediatric SS.So far,there are no classification criteria for pediatric SS that have been widely applied and validated,which needs to be further explored.The present review described the clinical characteristics and progress of classification criteria for pediatric SS,and compared pSS and sSS in affected children.