两性霉素B脂质体治疗早产儿侵袭性念珠菌感染的药学实践四例

Pharmaceutical practice of participating in treatment of invasive fungal infections in four premature infants with liposomal amphotericin B

早产儿是侵袭性念珠菌病高危群体。本文介绍药师参与的4例侵袭性念珠菌病早产儿的治疗过程,通过查阅相关文献,协助医师遴选抗真菌药物,确定早产儿剂量,预判疗程,识别ADR,及时评估药物的有效性和安全性。最终药师成功干预3例患儿的治疗方案,患儿转归良好,1例患儿转院治疗。

Preterm infants are at high risk for invasive candidiasis(IC).In this paper,pharmacists involved in the treatment of four preterm infants infected with IC.By consulting relevant literature,they assisted doctors in selecting antifungal drugs,determining the drug dosages,predicting the course of treatment,identifying adverse drug reactions,and evaluating the effectiveness and safety of antifungal drugs.Finally,the pharmacists successfully intervened in the treatment of three infants with good outcomes,and one infant was transferred to another hospital for treatment.