慢性阻塞性肺疾病合并支气管扩张症的研究进展

Research progress on chronic obstructive pulmonary disease with bronchiectasis

慢性阻塞性肺疾病(COPD)是一种异质性肺部状态,是常见的慢性呼吸系统疾病之一,患病率与病死率均较高。支气管扩张症是由各种病因引起的反复发生的化脓性感染,导致中小支气管反复损伤和(或)阻塞,致使支气管壁结构破坏,引起支气管异常和持久性扩张。支气管扩张症和COPD同时存在于同一患者的重叠综合征,即为支气管扩张症-慢性阻塞性肺疾病重叠综合征(BCOS)。BCOS是一种临床上常见的综合征,但有关BCOS临床特征及预后的研究很少。笔者通过大量文献检索分析,对COPD合并支气管扩张症的最新机制研究、临床特征研究及相关风险和预后研究进展进行全面阐述,旨在更清晰地认识这一综合征,并为BCOS的临床防治提供新的思路。

Chronic obstructive pulmonary disease(COPD)is a heterogeneous pulmonary condition and a common chronic respiratory disease with high morbidity and mortality.Bronchiectasis is a recurring pyogenic infection caused by various causes,resulting in repeated damage and/or obstruction of the small and medium bronchus,the destruction of the bronchial wall structure,bronchial abnormalities and persistent dilation.Bronchodilatation-chronic obstructive pulmonary disease overlap syndrome(BCOS)is a combination of bronchiectasis and COPD in the same patient.BCOS is a common clinical syndrome,but there are few studies on the clinical characteristics and prognosis of BCOS.Through a large number of literature retrieval and analysis,this review comprehensively expounds the latest mechanism research,clinical characteristics research,and related risk and prognosis research progress of COPD complicated with bronchiectasis,aiming at a clearer understanding of this syndrome and providing new ideas for clinical prevention and treatment of BCOS.