加味四君子汤对肾病综合征的改善作用及机制

The Improvement Effect and Mechanism of Jiawei Sijunzi Decoction(加味四君子汤) on Nephrotic Syndrome

目的 探讨加味四君子汤对肾病综合征的改善作用及机制。方法 纳入2021年3月—2023年6月医院收治的60例肾病综合征患者为该次研究对象,以随机数表法分为观察组(n=30)与对照组(n=30)。对照组进行常规治疗,观察组同时联合加味四君子汤进行治疗。对比两组患者的中医证候积分、24 h蛋白尿(24HUPQ)、尿微量白蛋白(MALB)、免疫功能指标(CD_(3)^(+)、CD_(4)^(+))、炎性因子水平(IL-6、TNF-α)及不良反应情况。结果 两组中医证候积分经治疗后均明显下降,且观察组下降幅度更大(P<0.05);治疗后观察组CD_(3)^(+)、CD_(4)^(+)水平明显高于对照组(P<0.05);治疗后观察组24HUPQ明显低于对照组,ALB明显高于对照组(P<0.05):治疗后观察组IL-6、TNF-α水平明显低于对照组(P<0.05);对照组不良反应发生率8.70%,观察组不良反应发生率为12.00%,两组无明显差异(P>0.05)。结论 加味四君子汤有助于提升肾病综合征的治疗效果,减轻患者的症状,其机制可能与免疫调节及抑制炎性反应有关。

Objective To explore the improving effect and mechanism of Jiawei Sijunzi Decoction(加味四君子汤)on nephrotic syndrome.Methods 60 patients with nephrotic syndrome admitted to the hospital from March 2021 to June 2023 were included in this study.They were randomly divided into the observation group(n=30)and the control group(n=30).The control group received routine treatment,while the observation group was also treated with Jiawei Sijunzi Decoction.Compare the TCM syndrome score,24 h proteinuria(24HUPQ),urinary microalbumin(ALB),immune function index(CD_(3)^(+),CD_(4)^(+)),and inflammatory factor level(IL-6,TNF-α)of the two groups And adverse reactions.Results The scores of TCM syndromes in the two groups decreased significantly after treatment,and the decrease was greater in the observation group(P<0.05);Afer treatment,the levels of CD_(3)^(+) and CD_(4)^(+) in the observation group were significantly higher than those in the control group(P<0.05),after treatment,24HUPQ in the observation group was significantly lower than that in the control group,and ALB was significantly higher than that in the control group,with statistically significant differences(P<0.05),IL-6 and TNF-α in the observation group after treatment.The level was significantly lower than that of the control group(P<0.05),the incidence of adverse reactions was 8.70%in the control group and 12.00%in the observation group,with no significant difference between the two groups(P>0.05).Conclusion Jiawei Sijunzi Decoction is helpful to improve the therapeutic effect of nephrotic syndrome and relieve the symptoms of patients.Conclusion Jiawei Sijunzi Decoction is helpful to improve the therapeutic effect of nephrotic syndrome and relieve the symptoms of patients.Its mechanism may be related to immune regulation and inhibition of inflammatory reaction.