补肾健骨方治疗骨质疏松性胸腰椎压缩性骨折的临床疗效观察

Clinical effffect of Bushen Jiangu Recipe in the treatment of osteoporotic thoracolumbar compressibility fractures

目的观察补肾健骨方治疗骨质疏松性胸腰椎压缩性骨折的临床疗效。方法选取150例肾虚血瘀型骨质疏松性胸腰椎压缩性骨折患者,按随机数字表法分为对照组和试验组各75例。2组均进行经皮椎体后凸成形术治疗,对照组术后予以常规西药治疗,试验组在对照组基础上予以补肾健骨方治疗。2组均治疗6周,随访6个月。比较2组临床疗效、治疗前后骨密度(T)、Oswestry功能障碍指数(ODI)、疼痛评分(VAS)、骨代谢指标、肝功能及术后6个月并发症发生率。结果治疗后,2组总有效率比较,差异无统计学意义(P>0.05)。2组T均升高(P<0.05),试验组高于对照组(P<0.05);2组VAS评分、ODI评分均降低(P<0.05),试验组VAS评分、ODI评分均低于对照组(P<0.05);2组PINP、β-CTX、25-(OH)D、BGP、血磷均升高(P<0.05),血钙均低于治疗前(P<0.05),试验组PINP、β-CTX、25-(OH)D、BGP、血磷均高于对照组(P<0.05),血钙低于对照组(P<0.05);2组ALT、AST与治疗前比较、治疗后组间比较,差异均无统计学意义(P>0.05),随访6个月,2组并发症发生率比较,差异无统计学意义(P>0.05)。结论补肾健骨方治疗肾虚血瘀型骨质疏松性胸腰椎压缩性骨折可增强疗效,提高骨密度和骨代谢指标,缓解疼痛,无肝损伤风险。

Objective To observe the clinical effect of Bushen Jiangu Recipe in the treatment of osteoporotic thoracolumbar compressibility fractures.Methods A total of 150 patients with osteoporotic thoracolumbar compressibility fracture of the kidney deficiency and blood stasis pattern were selected and randomly divided into a control group and an experimental group,with 75 cases in each.Both groups underwent a percutaneous kyphoplasty treatment,while the control group received a routine western medicine treatment after surgery,and the experimental group was treated with Bushen Jiangu Recipe on the basis of the control group.Both groups were treated for 6 weeks and followed up for 6 months.The clinical efficacy of the two groups after treatment,the bone mineral density(T),Oswestry Dysfunction Index(ODI),pain score(VAS),bone metabolism indicators,liver function before and after treatment,and the complication incidence six months after surgery were compared between the two groups.Results After treatment,there was no statistically significant difference in the total effective rate between the two group(P>0.05).Both groups showed an increase in T(P<0.05),with the experimental group being higher than the control group(P<0.05).The VAS score and ODI score of both groups were decreased(P<0.05),while their scores in the experimental group were lower than those in the control group(P<0.05).The levels of PINPsβ-CTX,25-(OH)D,BGP,and blood phosphorus were all higher than before treatment in both groups,and the experimental group was higher than the control group(P<0.05),while the level of blood calcium was lower than before treatment in both groups,and the experimental group was lower than the control group(P<0.05).There was no statistically significant difference in the levels of ALT and AST between the two groups compared to before treatment(P>0.05).After a 6-month follow-up,there was no statistically significant difference in the incidence of complications between the two groups(P>0.05).Conclusion Bushen Jiangu Recipe can enhance the curative effect,improve the bone density and bone metabolism indexes,alleviate pain,and has no risk of liver injury in the treatment of osteoporosis thoracolumbar compressibility fractures with the kidney deficiency and blood stasis syndrome.