八珍汤联合体外高频治疗对恶性肿瘤增效减毒作用分析

Synergistic and detoxifying effffect of Bazhen Tang combined with extracorporeal highfrequency therapy in the treatment of malignant tumors

目的探讨八珍汤联合体外高频治疗对恶性肿瘤增效减毒作用。方法按照随机数字表法将100例恶性肿瘤患者分成对照组和观察组。对照组采用化疗治疗+体外高频治疗,观察组在对照组治疗基础上联合八珍汤内服治疗。观察2组治疗前后中医证候积分、免疫功能指标、生活质量评分、无进展生存期与总生存期、药物不良反应变化,并比较2组治疗总获益率。结果观察组治疗后各项中医证候积分、CD8^(+)指标水平、药物反应总获益率均低于对照组(P<0.05),CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平、SF-36评分、无进展生存期与总生存期及治疗总获益率均高于对照组(P<0.05)。结论八珍汤内服联合体外高频治疗在抑制肿瘤发展进程中能起到增效减毒作用,可减轻化疗药物引起的不良反应,提高机体的免疫能力,改善患者的生存质量。

Objective To explore the synergistic and detoxifying effect of Bazhen Tang combined with extracorporeal high-frequency therapy in the treatment of malignant tumors.Methods According to the random number table method,100 patients with malignant tumors were divided into a control group and an observation group.The control group was treated with chemotherapy combined with extracorporeal high-frequency therapy,while the observation group was treated with Bazhen Tang orally on the basis of the control group.The changes in traditional Chinese medicine syndrome scores,immune function indicators,quality of life scores,progression-free survival and total survival,drug toxicity and side effects were observed before and after treatment in the two groups,and the total benefit rate was compared between the two groups.Results After treatment,the scores of TCM syndromes,the levels of CD8^(+)indicators,and the total benefit rate of drug toxicity and side effects were lower in the observation group than those in the control group(P<0.05).The levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+),the SF-36 scores,the progression-free survival and total survival,and the total benefit rate of treatment were all higher in the observation group than those in the control group(P<0.05).Conclusion The combination of oral administration of Bazhen Tang and extracorporeal high-frequency therapy can play a synergistic and detoxifying role in inhibiting the development of tumors,reducing the toxic side effects caused by chemotherapy drugs,improving the body's immune capacity,and improving the quality of life of patients.