摘要
生长激素(growth hormone,GH)/胰岛素样生长因子1(insulin growth factor-1,IGF-1)轴是下丘脑/垂体生长激素轴的重要组成部分,对儿童生长发育具有关键性作用。GH/IGF-1轴信号通路及其旁路的紊乱和异常通常在儿童时期表现为身材矮小。身材矮小的儿童通常需进行GH激发试验及IGF-1水平检测,以鉴别生长激素缺乏症(growth hormone deficiency,GHD)和其他导致生长迟缓的原因。该文对GH激发试验和IGF-1检测值进行分析与阐述,以期为临床儿童GHD的诊断提供参考。
The growth hormone(GH)/insulin-like growth factor 1(IGF-1)axis is an essential component of the hypothalamic-pituitary growth hormone axis and plays a crucial role in childhood growth and development.Disruptions and abnormalities in the GH/IGF-1 signaling pathway and its pathways typically manifest as short stature in children.Children with short stature often undergo GH stimulation testing and IGF-1 level measurements to differentiate growth hormone deficiency(GHD)from other causes of growth delay.This article aims to analyze and elucidate the values of GH stimulation testing and IGF-1 measurement,providing reference for the diagnosis of GHD in children.
作者
李堂
LI Tang(Department of Pediatric Endocrinology and Metabolism,Women and Children's Hospital,Qingdao University,Qingdao,Shandong 266000,China)
出处
《中国当代儿科杂志》
CAS
CSCD
北大核心
2023年第12期1193-1197,共5页
Chinese Journal of Contemporary Pediatrics
