辅助生殖技术对双胎出生体重不一致的影响

Impact of assisted reproductive technology on birth weight discordance in twins

目的探讨辅助生殖技术与双胎出生体重不一致(birth weight discordance in twins,BWDT)之间的关联。方法回顾性纳入2011年1月—2020年12月在广州医科大学附属第三医院出生且有完整的基本出生资料的双胎儿,采用多因素logistic回归分析探讨辅助生殖技术对BWDT发生的影响。结果共纳入3974对双胎儿,其中自然受孕组1431对,辅助生殖组2543对。辅助生殖组新生儿出生体重大于自然受孕组(P<0.001);辅助生殖组BWDT发生率低于自然受孕组(16.17%vs 21.09%,P<0.001)。多因素logistic回归分析(校正了母亲年龄、孕次、孕前体重指数、妊娠糖尿病、甲状腺功能减退、胎龄及绒毛膜性质等混杂因素)显示,在辅助生殖组和自然受孕组之间,双胎出生体重不一致的发生风险差异无统计学意义(P>0.05)。结论辅助生殖技术与BWDT的发生风险无明显关联。

Objective To explore the association between assisted reproductive technology(ART)and birth weight discordance in twins(BWDT).Methods A retrospective analysis was conducted on twin infants born between January 2011 and December 2020 at the Third Affiliated Hospital of Guangzhou Medical University,with complete basic birth data.The impact of ART on the occurrence of BWDT was identified by the multivariate logistic regression analysis.Results A total of 3974 pairs of twins were included,with 1431 conceived naturally and 2543 through ART.Neonates in the ART group had higher birth weights than those in the naturally conceived group(P<0.001).The incidence of BWDT was lower in the ART group compared to the naturally conceived group(16.17%vs 21.09%,P<0.001).The multivariate logistic regression analysis,adjusting for confounding factors such as maternal age,parity,pre-pregnancy body mass index,gestational diabetes,hypothyroidism,gestational age,and chorionic properties,showed no significant difference in the risk of BWDT between the ART and naturally conceived groups(P>0.05).Conclusions ART is not associated with the risk of BWDT.