m^(6)A甲基化在心肌缺血再灌注与心肌再生中的研究进展

Research progress of m^(6)A RNA methylation in myocardial ischemia reperfusion and myocardial regeneration

N6-甲基腺嘌呤(N6-methyladenosine,m^(6)A)RNA甲基化是最常见的、动态的、可逆的表观遗传RNA修饰,参与了包括心血管疾病在内的多种人类疾病的发病机制。最近的研究表明,m^(6)A RNA甲基化在心肌缺血再灌注及心脏再生中发挥重要调控作用。重要的是,这些新发现表明,通过改变m^(6)A的调节因子来控制m^(6)A的水平,可能是防止心脏功能恶化促进心脏修复的一种新颖而有力的策略。

N6-methyladenosine(m^(6)A) RNA methylation is the most common,dynamic and reversible epigenetic RNA modification and is involved in the pathogenesis of many human diseases,including cardiovascular diseases.Recent studies have shown that m^(6)A RNA methylation plays an important regulatory role in myocardial ischemia-reperfusion and cardiac regeneration.Importantly,these new findings suggest that controlling m^(6)A levels by altering the regulatory factors of m^(6)A may be a novel and powerful strategy to prevent the deterioration of cardiac functions and promote cardiac repair.