摘要
目的:探讨血清淀粉样蛋白A在肺炎支原体感染患者中的诊断价值,为肺炎支原体早期诊断提供依据。方法:选取2020年1月-2022年1月我院收诊的240例儿童呼吸道感染患者作为研究对象,其中80例肺炎支原体感染患者为A组,80例普通呼吸道感染患者为B组,同一时期在儿保科选择健康查体者80例作为对照组,测定各组患者血常规、C反应蛋白(C-reactive protein,CRP)、SAA水平,并进行统计分析。结果肺炎支原体A组与普通呼吸道感染B组比较白细胞总数(WBC)、中性粒细胞比例(N)、CRP差异无统计学意义(P>0.05),肺炎支原体A组与普通呼吸道感染B组比较,普通呼吸道感染B组SAA水平明显高于肺炎支原体A组,SAA差异均有统计学意义(P<0.05),肺炎支原体A组、普通呼吸道感染B组分别与正常对照组比较白细胞总数(WBC)、中性粒细胞比例(N)、CRP、SAA差异均有统计学意义(P<0.05)。恢复期抽血测定肺炎支原体A组SAA、CRP发现,恢复期SAA平均值(28.08±17.94)mg/L,恢复期CRP平均(4.3±1.62)mg/L。较治疗前两个值均有显著下降P<0.001(95%CI分别为SAA35.52~70.43,CRP4.65~10.56),控制炎症后两个指标下降显著。结论血清淀粉样蛋白A可作为早期鉴别诊断肺炎支原体与普通呼吸道感染有效指标,控制肺炎支原体感染后SAA和CRP两个指标下降显著,可用于监测肺炎支原体感染的治疗效果。
Objective:To explore the diagnostic value of serum amyloid A in patients with Mycoplasma pneumoniae infection,so as to provide basis for early diagnosis of Mycoplasma pneumoniae.Methods:Children with respiratory tract infection treated in Xinxian people's hospital were studied,including 80 patients with Mycoplasma pneumoniae infection as group A and 80 patients with ordinary respiratory tract infection as group B.in the same period,80 healthy physical examiners were selected as the control group in the Department of Pediatrics.The diagnostic value of serum amyloid A in patients with Mycoplasma pneumoniae infection and its significance in the evaluation of treatment effect were analyzed.Results:There was no significant difference in total leukocyte(WBC),neutrophil ratio(n)and CRP between Mycoplasma pneumoniae group A and general respiratory tract infection group B(P>0.05).Compared with general respiratory tract infection group B,the SAA level of general respiratory tract infection group B was significantly higher than that of Mycoplasma pneumoniae group A(P<0.05)There were significant diferences in total white blood cell(WBC),neutrophil ratio(n),CRP and SAA between group B and normal control group(P<0.05).The SAA and CRP of Mycoplasma pneumoniae group A were measured by blood sampling in the recovery period.It was found that the average value of SAA in the recovery period was(28.08±17.94)mg/L and the average value of CRP in the recovery period was(4.3±1.62)mg/L.Compared with the two values before treatment,the two indexes decreased significantly(P<0.001)(95%CI:SAA 35.52~70.43,CRP 4.65~10.56,respectively).After controlling inflammation,the two indexes decreased significantly.Conclusion:Serum amyloid A can be used as an effective index for early differential diagnosis of Mycoplasma pneumoniae and common respiratory tract infection.After controlling Mycoplasma pneumoniae infection,SAA and CRP decreased significantly,which can be used as an index for the treatment effect of Mycoplasma pneumoniae infection.
作者
虞改雪
张善虎
YU Gaixue;ZHANG Shanhu(Epartment of Internal Medicine,Shenxian People's Hospital,shandong shenxian 252400)
出处
《医学检验与临床》
2023年第10期10-13,共4页
Medical Laboratory Science and Clinics