摘要
糖尿病肾脏病是糖尿病的并发症之一,可进展至终末期肾脏病。近年研究发现,miRNA-21可通过调控转化生长因子-β1(TGF-β1)/Smads、磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(AKT)、Wnt/β-连环蛋白等信号通路影响糖尿病肾脏病的进展。中药对miRNA-21表达具有调节作用,可以靶向miRNA-21调控TGF-β1/Smads、磷酸酶张力蛋白同源物/PI3K/AKT/哺乳动物雷帕霉素靶蛋白、过氧化物酶体增殖物激活受体等信号转导,引发信号级联反应,干预纤维化、炎症、氧化应激、自噬等病理过程。就miRNA-21在糖尿病肾脏病中的作用机制及中药对其的干预作用进行综述。
Diabetic kidney disease is one of the complications of diabetes,which can progress to end-stage renal disease.In recent years,it has been found that miRNAs have become a research hotspot,with miRNA-21 regulating transforming growth factorβ1(TGF-β1)/Smads,phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT),Wnt/β-catenin and other signaling pathways to promote the progress of diabetic kidney disease.Studies have showed that traditional Chinese medicine has a regulatory effect on the expression of miRNA-21 and can target miRNA-21 to regulate TGF-β1/Smads,phosphatase and tensin homolog/PI3K/AKT/mammalian target of rapamycin(mTOR),peroxisome proliferator activated receptors and other signal transduction pathways to trigger signal cascade reactions,which intervene in pathological processes such as fibrosis,inflammation,oxidative stress and autophagy.In this article,the role of miRNA-21 in diabetic kidney disease and the intervention of traditional Chinese medicine were summarized,in order to provide some reference for the treatment of diabetic kidney disease and the development of new drugs.
作者
陈宇
黄国东
覃婷
张泽朝
沈小楠
许艺镡
刘少芳
CHEN Yu;HUANG Guodong△;QIN Ting;ZHANG Zechao;SHEN Xiaonan;XU Yitan;LIU Shaofang(Guangxi Internatonal Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530000,China;Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine)
出处
《天津医药》
CAS
北大核心
2023年第12期1387-1392,共6页
Tianjin Medical Journal
基金
国家自然科学基金资助项目(81960913)
广西名中医传承工作室(桂中医药科教发[2021]6号)
广西医学高层次骨干人才培养“139”计划项目(G202002014)
广西岐黄学者培养项目(桂中医药科教发[2021]10号)
广西中医药重点学科(中西医结合临床)建设项目(桂中医药科教发[2020]14号)。