胞磷胆碱联合帕利哌酮治疗精神分裂症患者的效果

Effects of Citicoline combined with Paliperidone in treatment of patients with schizophrenia

目的:观察胞磷胆碱联合帕利哌酮治疗精神分裂症患者的效果。方法:选取2020年10月至2022年10月该院收治的96例精神分裂症患者进行前瞻性研究,按照随机数字表法将其分为研究组和对照组各48例。对照组予以帕利哌酮治疗,研究组在对照组基础上联合胞磷胆碱治疗,共治疗2个月。比较两组临床疗效,治疗前后阳性和阴性症状量表(PANSS)评分、神经因子[脑源性神经营养因子(BDNF)、胶质细胞源性神经营养因子(GDNF)]水平,以及不良反应发生率。结果:研究组治疗总有效率为91.67%(44/48),高于对照组的75.00%(36/48),差异有统计学意义(P<0.05);治疗后,研究组阳性症状、阴性症状、一般精神病理等PANSS各维度评分和总分均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组BDNF、GDNF水平均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:胞磷胆碱联合帕利哌酮治疗精神分裂症患者可提高治疗总有效率和神经因子水平,降低PANSS评分,效果优于单纯帕利哌酮治疗。

Objective:To observe effects of Citicoline combined with Paliperidone in treatment of patients with schizophrenia.Methods:A prospective study was conducted on 96 patients with schizophrenia admitted to this hospital from October 2020 to October 2022.They were divided into study group and control group according to the random number table method,48 cases in each.The control group was treated with Paliperidone,while the study group was treated with Citicoline on the basis of that of the control group.After 2 months of treatment,the clinical efficacy,the positive and negative symptom scale(PANSS)score,the nerve factor levels[brain-derived neurotrophic factor(BDNF),glial cell line-derived neurotrophic factor(GDNF)],and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the study group was 91.67%(44/48),which was higher than 75.00%(36/48)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of positive symptoms,negative symptoms,general psychopathology and other PANSS dimensions and the total score in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of BDNF and GDNF in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Citicoline combined with Paliperidone in the treatment of the patients with schizophrenia can improve the total effective rate and nerve factor levels and reduce the PANSS scores.Moreover,it is superior to single Paliperidone treatment.